脑梗死患者血同型半胱氨酸水平与颈动脉粥样硬化程度的相关性分析

Analysis the Correlation of Blood Homocysteine Level and Carotid Atherosclerosis Degree in the Patients with Cerebral Infarction

目的探讨脑梗死患者中血同型半胱氨酸(Hcy)水平与其颈动脉粥样硬化程度的相关性。方法分别测定46例脑梗死患者及40名对照者的血Hcy水平并同时检测其血脂、血糖及叶酸和维生素B12水平,并进行颈动脉彩色多普勒超声检查,记录颈动脉粥样硬化斑块的数量和颈总动脉分叉处内膜中层厚度(intima-media thickness,IMT)。结果脑梗死组的血Hcy水平显著高于对照组,血清叶酸以及维生素B12水平显著低于对照组,而两组之间的血糖及血脂水平无差异。将脑梗死组按颈动脉彩色多普勒超声检查斑块的数量分为无斑块组、单一斑块组和多个斑块组比较其血Hcy水平发现其组间有差异且有统计学意义(P<0.05),叶酸和维生素B12水平的组间差异无统计学意义;血Hcy水平与IMT值成正相关关系且有统计学意义(P<0.05),叶酸和维生素B12水平与IMT值成负相关关系但无统计学意义。结论高同型半胱氨酸血症是形成颈动脉粥样斑块的危险因素之一,也是导致颈总动脉分叉处内膜中层增厚的原因之一。

Objective To investigate the correlation of blood homocysteine level and carotid atheroselerosis degree in the patients with cerebral infarction. Methods 46 cases were determined patients with cerebral infarction and 40 healthy controls blood Hey level and at the same time testing its blood fat, blood sugar and folio acid and vitamin B12 levels, and the carotid artery color doppler ultrasound, record the number of carotid atheroselerotic plaque and the intimamedia thickness （IMT）. Results Cerebral infarction of the blood of the group Hcy were significantly higher than those in the control group, serum folio acid and vitamin B12 were significantly lower than those of the control group, and there＇s no difference between the two groups in terms of blood sugar and blood fat level. According to the carotid artery color doppler ultrasound plaque, the cerebral infarction group is divided into the number of no plaques group, a single plaques group and multi plaques group. There＇s a difference between the Hey level of the groups with a statistically significance （P〈 0.05）, and the differences of folie acid and vitamin Bl2 levels have no statistically significance. Blood Hcy level and IMT values are positively correlated with a statistically significance （P〈 0.05）, folic acid and vitamin B12 levels and IMT values into negative relationship but was not statistically significant. Conclusions Hyperho mocysteinemia is one of the risk factors for the formation of carotid atheromatous plaque and it＇s also one of the causes to lead the rising of IMT value.