胆囊结石或胆囊切除术与大肠癌关系的Meta分析

Meta-Analysis on Correlation of Cholecystolithiasis or Cholecystectomy with Colorectal Neoplasm

目的:研究胆囊结石、胆囊切除术与大肠癌发生的关系。方法:利用微机检索及溯源等方法,按照纳入标准收集挑选所有有关中国人群胆囊切除术、胆囊结石与大肠癌发生关系的病例对照研究原始文献。利用Revman4.2软件对挑选出的文献进行荟萃分析。结果:9篇文献符合入选标准,由随机效应模型计算得到的胆囊切除术与大肠癌发生关系的合并OR值为2.31,95%可信区间为(1.41～3.79),总效应测定结果Z=3.31,胆囊结石与大肠癌发生关系的合并OR值为1.98,95%可信区间为(1.48～2.64),Z=4.63。5篇文献同时探讨了胆囊结石、胆囊切除与大肠癌的关系,对其分别进行统计,比较分析得出,合并OR值为5.02,95%的可信区间为(2.89～8.73),Z=5.72,P<0.001。结论:胆囊切除术、胆囊结石可以增加大肠癌发生的危险性,并且胆囊结石与大肠癌的发生关系更为密切。

Objective：To investigate the correlation of cholecystolithiasis or cholecystectomy with colorectal cancer in Chinese population.Methods All case-control articles on the correlation of cholecystectomy or cholecystolithiasis with colorectal neoplasm in Chinese population were collected through some computer database and handwork research,and according to adoptive criteria,Revman 4.2 software was applied to process the data.Results Nine articles were selected.The randomized effect model of meta-analysis was selected to calculate the pooled OR.The total OR between cholecystectomy and colorectal cancer was 2.31,with a 95%CI of 1.41～3.79.The overall effect Z was equ-al to 3.31.The total OR between cholecystolithiasis and colorectal cancer was 1.98,with a 95%CI of 1.48～2.64.The overall effect Z was equal to 4.63.The total OR between cholecystolithiasis and cholecystectomy was 5.02,with a 95%CI of 2.89～8.73.The overall effect Z was equal to 5.72.Conclusion Cholecystectomy or cholecystolithiasis is associated with colorectal cancer in Chinese population.Furthermore,there is a closer relationship between cholecystolithiasis and color-ectal cancer.