糖尿病周围神经病变患者血尿酸水平及相关因素的临床分析

Level of UA and related factors in DPN patients

目的探讨糖尿病周围神经病变(diabetic peripheral neutropathy,DPN)患者血尿酸水平的变化及其与相关因素的关系。方法对2008年7月～2010年12月间来该院内分泌科住院的2型糖尿病(T2DM)患者1 443例,检测血尿酸及HbA1c、HDL-c、LDL-c、uMAL、hs-CRP、腰围等指标,计算高尿酸血症(hyperuricemia,HUA)发病率,并用多元Logistic回归分析确定DPN发病的各危险因素。结果 DPN患者平均血尿酸水平较非DPN患者水平升高,且HUA在DPN中的发生率更高,差异具显著性意义(P<0.01或P<0.05);DPN发病各危险因素多元Logistic回归分析结果显示,与非DPN患者相比,DPN患者的LDL-c、hs-CRP、uMAL、腰围更高,差异有显著性(P<0.01或P<0.05),HDL-c更低、HbA1c增高,但差异无显著性(P>0.05)。结论血尿酸水平与DPN密切相关,监测并控制血尿酸水平有利对DPN进行有效干预并改善其预后。

Objective To study the relationship between the change of the level of UA and its relation with the correlative factors in the DPN patients.Methods The levels of BUA,HbA1c,HDL-c,LDL-c,of 1 443 cases T2DM from endocrine division were tested,and the morbidity rates of HUA were calculated,with morbidity factor identified by using Multiple logistic regression.Results The average blood uric acid level patients in DPN were higher compared with non DPN patients which had statistically significant difference（P0.05 or P0.05）.The risk factors of DPN analyzed by multiple Logistic regression showed that the LDL-c,hs-CRP,uMAL and waistline in the DPN,compared with non DPN patients,were significantly different,but HDL-c,HbA1c were of little difference（P0.05）.Conclusion The level of UA and DNP are closely related.Monitor and control of the level of UA is benefitial for the effective intervention and maybe improve its outcome in DPN patient.