电针治疗阻塞性睡眠呼吸暂停低通气综合征的P300临床研究

Observation on the electroacupuncture in treating obstructive sleep apnea hypoventilation syndrome and its impact on the P300 test

目的观察电针对阻塞性睡眠呼吸暂停低通气综合征(OSAHS)的临床疗效及其对患者认知功能的影响。方法本研究采用前瞻性、非对比性病例系列设计,利用多导睡眠监测评价疗效,利用观察病人认知变化。电针治疗22例OSAHS的连续病例,并于治疗前及治疗6周后进行多导睡眠监测和P300检测。同期对11例健康成人进行P300检测,观察P300指标稳定性。结果 22例OSAHS患者电针治疗后睡眠呼吸暂停低通气指数明显下降(P<0.05),最低血氧饱和度值明显上升(P<0.05),P300潜伏期及反应时间均明显缩短(P<0.01)。11例健康成人6周前后P300潜伏期及反应时间均无明显差异(P>0.05)。结论电针治疗OSAHS可减少睡眠时呼吸暂停和低通气次数,提高最低血氧饱和度,缩短P300潜伏期和反应时间,改善患者认知功能,对特殊职业的OS-AHS患者更有意义。

Objective To observe the clinical effects of electroacupuncture in treating obstructive sleep apnea hypoventilation syndrome（OSAHS） and the impact on the patients＇cognitive function.Methods 22 patients with OSAHS were treated by electroacupuncture for six weeks as a course,and accepted two polysomnographies and two P300 tests prior to treatment and after 6-week treatment.At the same time,11 healthy adults accepted no treatments but two P300 tests together with the patients.Result After the course of treatment,patients＇Cz,Fz,Pz latency and P300 reaction time shortened（P0.01）.And the apnea hypopnea index reduced.（P0.05）The lowest oxygen saturation increased.（P0.05） The 11 healthy adults＇ P300 test results had no significant changes（P0.05）.Conclusion Electroacupuncture can reduce the apnea hypopnea index,increase the oxygen saturation,shorten P300 latency and reaction time of patients with OSAHS,and improve cognitive function.This therapy is more meaningful in treating patients with OSAHS of special occupations.