3[1]Podolsky DK.Inflammatory bowel disease.N Engl J Med 2002;347:417-429
4[2]Xavier RJ,Podolsky DK.Unravelling the pathogenesis of inflammatory bowel disease.Nature 2007;448:427-434
5[3]Elson CO,Cong Y,Brandwein s,Weaver CT,McCabe RP,Mahler M,Sundberg JP,Leiter EH.Experimental models to study molecular mechanisms underlying intestinal inflammation.Ann N Y Acad Sci 1998;859:85-195
6[4]Ewaschuk JB,Tejpar QZ,Soo I,Madsen K,Fedorak RN.The role of antibiotic and probiotic therapies in current and future management of inflammatory bowel disease.Curr Gastroenterol Pep 2006;8:486-498
7[5]Gionchetti P,Rizzello F,Helwig U,Venturi A,Lammers KM,Brigidi P,Vitali B,Poggioli G,Miglioli M,Campieri M,Prophylaxis of pouchitis onset with probiotic therapy:a double-blind,placebo-controlled trial.Gastroenterology 2003;124:1202-1209
8[6]Sutherland L,Singleton J,Sessions J,Hanauer S,Krawitt E,Rankin G,Summers R,Mekhjian H,Greenberger N,Kelly M.Double blind,placebo controlled trial of metronidazole in Crohn's disease.Gut 1991;32:1071-1075
9[7]Rakoff-Nahoum S,Paglino J,Eslami-Varzaneh F,Edberg S,Medzhitov R.Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis.Cell 2004;118:229-241
10[8]Lee J,Mo JH,Katakura K,Alkalay I,Rucker AN,Liu YT,Lee HK,Shen C,Cojocaru G,Shenouda S,Kagnoff M,Eckmann L,Ben-Neriah Y,Raz E.Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells.Nat Cell Biol 2006;8:1327-1336