铜(Ⅱ)烟酸与L-α-丙氨酸三元配合物的固相合成和表征及抑菌活性

Solid phase synthesis,characterization and antibacterial activity of copper(Ⅱ) with nicotinic acid and L-α-alanine

在室温条件下,通过固相反应合成了铜(Ⅱ)的烟酸、L-α-丙氨酸三元配合物,采用元素分析、红外光谱、紫外光谱以及X-射线粉末衍射光谱对配合物进行了表征。结果表明,烟酸脱掉羧酸上的质子以酸根的形式与铜离子配位,而吡啶环上的氮原子未参与配位,L-α-丙氨酸的氨基氮与羧基氧同时与铜离子配位。抑菌活性试验表明,该配合物对金黄色葡萄球菌、枯草芽孢杆菌、大肠杆菌、铜绿假单胞菌、嗜水气单胞菌和耶尔森氏菌都具有抑菌活性,对枯草芽孢杆菌的抑菌效果最好,配合物浓度为0.5 mmol/L时,抑菌圈直径达13.4 mm,最低抑菌浓度为0.031 25 mmol/L。

A copper（Ⅱ） complex with nicotinic acid and L α alanine was synthesized by the method of room temperature solid phase synthesis.The complex was characterized through elemental analysis,infrared spectra,ultraviolet spectra and X ray powder diffraction.The results showed that the COO group of nicotinic acid and the amino nitrogen and carboxylic oxygen of L α alanine coordinated with Cu2＋.Antibacterial test displayed that the complex have a certain antibacterial activity against Staphylococcus aureus,Bacillus subtilis,Escherichia coli,Bacillus aeruginosus,Aeromonas hydrophila and Yersinia intermedia,and the activity against Bacillus subtilis was the strongest with the inhibition diameter of 13.4 mm at the concentration of 0.5 mmol/L.The minimal inhibitory concentration of the complex against bacillus subtilis was 0.031 25 mmol/L.