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阿尔茨海默病的免疫治疗研究进展 被引量:2

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摘要 阿尔茨海默病(AD)是老年人常见的神经系统变性疾病,主要以记忆力减退、认知功能障碍、精神行为异常为临床特征;以细胞外老年斑和神经元内神经纤维缠结为病理特征。老年斑的中央核心是Aβ,神经纤维缠结是由异常磷酸化Tau蛋白产生的双股螺旋纤维所组成。
作者 罗强 王永红
出处 《中国老年学杂志》 CAS CSCD 北大核心 2012年第4期866-868,共3页 Chinese Journal of Gerontology
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  • 1Hardy J,Selkoe DJ.The amyloid hypothesis of Alzheimer's disease:progress and problems on the road to therapeutics[J].Science,2002 ; 297(5580):353-6.
  • 2Esler WP,Wolfe MS.A portrait of Alzheimer secretases-new features and familiar faces[J].Science,2001 ;293 (5534):1449-54.
  • 3Schenk D,Barbour R,Dunn W,et al.Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse[J].Nature,1999 ;400(6740):173-7.
  • 4Morgan D,Diamond DM,Gottschall PE,et al.A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease[J].Nature,2000 ;408 (6815):982-5.
  • 5Gilman S,Koller M,Black RS,et al.Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial[J].Neurology,2005 ;64(9):1553-62.
  • 6Winblad BG,Minthon L,Floesser A,et al.Results of the first-in-man study with the active Abeta immunotherapy CAD106 in Alzheimer patients[J].Alzheimer Dement,2009 ;5 (4suppll):113-4.
  • 7Ferrer I,Rovira MB,Guerra MLS,et al.Neuropathology and pathogenesis of encephalitis following amyloid-beta imnunization in Alzheimer's disease[J].Brain Pathol,2004; 14(1):11-20.
  • 8Frenkel D,Fewachter I,Van Leuven F,et al.Reduction of beta amyloid plaques in brain of transgenic mouse model of Alzheimer's disease by EFRH-phage immunization[J].Vaccine,2003 ;21 (11-12):1060-5.
  • 9胡金家,李国营,汪华侨,李少兵,袁群芳,谢瑶,姚志彬.淀粉样β蛋白42及其亚单位疫苗预防接种对APPSWE转基因小鼠学习记忆能力的保护作用(英文)[J].中国临床康复,2005,9(13):184-186. 被引量:8
  • 10Solomon B,Koppel R,Frankel D,et al.Disaggregation of Alzheimer beta-amyloid by site-directed mAb[J].Proc Natl Acad Sci USA,1997 ;94(8):4109.

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