化疗药物引起的急性弥漫性肺损伤—2例报告并文献复习

Acute extensive pulmonary toxicity from chemotherapeutic agents-Two cases report and review of literatures

目的探讨药物性急性肺损伤的诊断、临床特点、治疗和预后。方法对2例化疗后导致急性呼吸窘迫综合征患者的临床资料进行分析,并对国内外文献进行复习。结果化疗药物可引起急性肺损伤,常表现为急性呼吸窘迫综合征,临床特点包括发热、干咳、呼吸急促,肺部CT表现为双肺弥漫性磨玻璃样影。结论急性药物性肺损伤的诊断为排除性,早期诊断十分重要,需及时停用相关药物,必要时加用糖皮质激素治疗。

Objective This study was aimed to evaluate the diagnosis, clinical features, therapy and prognosis of chemotherapeu- tic agents-induced acute pulmonary toxicity. Methods We reported two cases of chemotherapeutic agents-induced acute pulmonary toxici- ty patients with review of literatures. Results Most chemotherapeutic agents may induce acute pulmonary toxicity, mostly presented as a- cute respiratory distress syndrome, and clinical features included fever, cough, dyspnea, etc. CT scan of chest showed extensive bilateral ground-glass opacities. Conclusion The disgnosis is usually one of exclusion, early diagnosis is very important, and stopping the drug is sufficient therapy for most drug toxicities, but corticosteroid administration may also be necessarily needed.