Churg-Strauss综合征肺损害1例并文献复习

Lung Damage of Churg-Strauss Syndrome:A case report and a review of the literature

目的加深对Churg-Strauss综合征又名变应性肉芽肿血管炎(CSS)的认识。方法通过对1例CSS病例的诊断、治疗及相关文献进行研究学习,分析Churg-Strauss综合征的病因、临床症状、实验室检查、影像学表现、诊断、鉴别诊断及治疗。结果 CSS病因不清,临床表现无特异性,可累及多系统器官,最常见的临床表现是哮喘及血管炎引起的肺部表现,特征性的病理表现为外周血嗜酸粒细胞增多,目前治疗首选激素,预后较好。结论 Churg-Strauss综合征是一种少见的系统性血管炎,临床缺乏特异性表现,易被误诊,当患者表现为哮喘、外周血嗜酸性粒细胞增多及肉芽肿性血管炎时,应高度怀疑此病。

Objective To further understand and improve the diagnostic accuracy of Churg - Strauss Syndrome. Methods We analyzed the etiology, clinical manifestations, athological characteristic, imaging manifestations, diagnosis, Differential diagnosis and the therapy of Churg-Strauss Syndrome after diagnosing one case and reviewing sorrte literatures. Results The etiology remained unknown, and the clinical manifestations were nonspccific. The major clinical symptoms was asthma, and extrapulmonary manifestations of systemic vaseulitis. The pathological manifestation was characterized by hypereosinophilia. For treatment, systemic corticosteroid was helpful. The prognosis was good for most patients. Conclusion Churg-Stranss Syndrome is a rare system vasculitis disease, and easily misdiagnosed. We should highly suspected Churg-Stranss Syndrome, when the patients present asthma, eosinophilia, and vasculitis with granuloma.