水飞蓟宾胶囊对急性脑梗死患者氧化应激水平和炎症指标的影响

The Efficacy of Silibinin Capsules on Oxidative Stress and Inflammation in Patients with Acute Cerebral Infarction

目的:探讨水飞蓟宾胶囊对脑梗死患者氧化应激和炎症的影响。方法:75例急性脑梗死患者随机分为常规治疗组(42例)和水飞蓟宾治疗组(33例),随访1个月。采集患者入院后第1天、第7天血液样本,检测血清一氧化氮(NO)、内皮素(ET)和氧化应激水平。实验末期评估患者治疗前后临床疗效。结果:经过1月的治疗,两组患者总有效率的差异无统计学意义(88.09%vs84.85%,P>0.05)。但水飞蓟宾治疗组神经功能和日常生活能力的恢复明显优于常规治疗组(P<0.05);同时入院后第7天血清NO、ET和氧化应激的水平较常规治疗组显著降低(P<0.05)。两组药物不良反应差异无统计学意义(P>0.05)。结论:水飞蓟宾胶囊对治疗急性脑梗死有较好的临床疗效,作用机制可能与抗炎抗氧化有关。

Objective:To observe the clinical effect of silibinin capsules in treating acute cerebral infarction in adult.Method:Seventy-five patients with acute cerebral infarction were enrolled and randomly divided into two groups:conventional therapy group(n=42) and silibinin capsules treatment group(n=33).After admission,on the 1st day and 7th day blood of two group were collected for detection of the levels of NO,ET and oxidative stress.The treatment lasted 1 month and clinical efficacy was assessed at the end of the experiment.Results:The efficacy of conventional therapy group and silibinin capsules treatment group was 84.85% and 88.09% respectively(P>0.05).But the recovery of neurological and activity of daily living in silibinin capsules treatment group was much better compare to the conventional therapy group(P<0.05),so as the levels of NO,ET and oxidative stress in serum(P<0.05).No significant difference about adverse effect of silibinin capsules was observd in both group(P>0.05).Conclusion:Silibinin capsules might be a candidate for the treatment of acute cerebral infarction in adult,whose clinical effects might be related to the properties of anti-inflammation and antioxidant.