干扰素辅助小剂量HA方案治疗慢性粒细胞白血病29例疗效观察

Clinical observation of interferon combined with low dose HA assisted in the treatment of 29 cases with chronic myelocytic leukemia

目的探讨干扰素辅助小剂量HA方案治疗慢性粒细胞白血病的临床疗效。方法选择2002年3月~2011年2月在我院住院的确诊为慢性粒细胞白血病患者58例作为研究对象,随机将其分为观察组和对照组,每组各29例。对照组予以小剂量HA方案,即高三尖杉酯碱（HHT）＋阿糖胞苷（Ara-c）。观察组在对照组小剂量HA方案治疗基础上加用重组α-2b干扰素。结果观察组血液学缓解总有效率为93.10%,对照组为72.41%,两组比较差异有统计学意义（P〈0.05）。观察组细胞遗传学缓解总缓解率为65.51%,对照组为37.93%,两组比较差异有统计学意义（P〈0.05）。两组患者副作用及副反应发生率比较差异无统计学意义（P〉0.05）。结论重组α-2b干扰素联合小剂量HA方案治疗慢性粒细胞白血病具有协同作用,可产生较好的细胞遗传学反应,降低白细胞效果明显,血液学缓解率高,值得临床推广应用。

Objective To explore the clinical effectiveness interferon combined with low dose HA assisted in the treatment of patients with chronic myelocytic leukemia.Methods 58 cases from March 2002 to February 2011 definitely diagnosed as chronic myelocytic leukemia were selected as the subjects and divided into two group including observation group and control group,each of which had 29 cases.In the control group,the patients received low dose HA treatment as homoharringtonine（HHT） combined with cytosine arabinoside（Ara-c）.In the observation group,the patients received regrouped α-2b interferon based on the program of control group.Results The total effective rates of hematological release were 93.10% in observation group and 72.41% in control group with significant difference between two groups（P 0.05）.The total remission rates of cytogenetics were 65.51% in observation group and 37.93% in control group with statistical significance between two groups（P 0.05）.There was no significant difference for the incidence of side effects in two groups（P 0.05）.Conclusion Low dose HA treatment combined with regrouped α-2b interferon being worthy of generalization have synergistic effect on chronic myelocytic leukemia and can produce favorable cytogenetic response with evidently decreased leukocyte and high remission rate of hematology.