血清视黄醇结合蛋白4水平与急性冠状动脉综合征的关系研究

Analysis of the relationship between serum retinal binding protein 4 level and acute coronary syndrome

目的探讨血清视黄醇结合蛋白4(RBP4)水平与急性冠状动脉综合征(acute coronary syndrome,ACS)发生的相关性。方法选择因典型ACS症状入院并经冠状动脉造影证实的冠心病患者136例作为实验组(A组),并根据全球急性冠状动脉事件注册(global registry of acute coronary events,GRACE)危险评分系统将其分为低危组(50例)和高危组(86例);选择因不典型胸痛入院并经冠状动脉造影证实的非冠心病患者89例例作为对照组(B组),分别测定各组RBP4、C-反应蛋白(CRP)、空腹血糖(FBG)、糖化血红蛋白(HbA1c)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)及入院后血压水平并进行比较。结果 A组RBP4、CRP、HbA1c、FBG、TC、LDL-C及收缩压水平明显高于B组,差异均有统计学差异(P<0.05或P<0.01),且A组中高危组的RBP4水平显著高于低危组,差异有统计学意义(P<0.05),而CRP、HbA1c、FBG、TC、LDL-C及收缩压水平较低危组有所升高,但差异无统计学意义(P>0.05)。结论 RBP4是ACS的预测因子和危险因素,更是ACS高危患者的预测因子。

Objective To study the correlation between the level of serum retinal binding protein 4（RBP4） and the incidence of acute coronary syndrome.Methods 136 cases of patients with acute coronary syndrome who had typical signs of acute coronary syndrome and diagnosed by coronary angiography were chosen as experiment group（group A）,which was divided into low-risk group（50 cases） and high-risk group（86 cases） according to the GRACE system.Meanwhile,89 cases of patients with atypical chest discomfort who were not diagnosed with acute coronary syndrome by coronary angiography were selected as control group（group B）.The level of RBP4,CRP,FBG,HbAlc,TC,LDL-C and blood pressure were measured and compared among the groups.Results The level of RBP4,CRP,FBG,HbAlc,TC,LDL and blood pressure of the group A were statistically significant higher than those of group B（P 0.05 or P 0.01）.In group A,the level of RBP4 was significantly higher of the high-risk group than that of the low-risk group（P 0.05）;the level of CRP,HbA1c,FBG,TC,LDL-C of high-risk group were higher than those of low-risk group,but the differences were not significant（P 0.05）.Conclusion RBP4 is a predictor and high risk factor of acute coronary syndrome,which is also a predictor of patients with high risk of acute coronary syndrome.