高同型半胱氨酸血症与脑血管病的关系

Relationship between hyperhomocysteinemia and cerebrovascular disease

目的研究同型半胱氨酸(Hcy)水平与脑血管病(CVD)的相关因素,进一步评价Hcy在动脉狭窄的发生、发展中的作用。方法用荧光偏正免疫分析法分别测定脑梗死组、脑出血组和正常对照组的血浆Hcy水平,用颈部彩超判定颈部血管狭窄程度。结果脑梗死组及脑出血组的Hcy水平显著高于正常对照组,并且Hcy水平随着血管狭窄程度的增加而增高。结论高同型半胱氨酸血症是脑血管病的一个重要的独立的危险因素。同时也是动脉硬化的重要危险因素。

Objective To investigate the correlation factor between the homocysteine（Hcy） levels and cerebrovascular disease（CVD） and make further evaluation to the role of Hcy in the onset,development of arterial stenosis.Methods Plasma Hcy level of cerebral infarction group,cerebral hemorrhage group and the normal control group were determined by fluorescence polarization immunoassay;the degree of angiostegnosis of the neck was determined by neck Doppler ultrasound.Results Hcy levels of cerebral infarction and cerebral hemorrhage group were significantly higher than that of the normal control group,and Hcy levels increased with the increasing of stenosis degree.Conclusion Hyperhomocysteinemia is an important independent risk factor in cerebrovascular diseases and also an important risk factor for atherosclerosis.