前列地尔注射液与麝香保心丸联合治疗冠心病心绞痛的疗效观察

Observation of the curative effect on Alprostadil Injection combined with Shexiang Baoxin Wan on angina pectoris

目的观察前列地尔注射液与麝香保心丸联合应用对冠心病心绞痛的治疗效果。方法将120例心绞痛患者采用随机单盲对照法分为三组,对照组给予口服硝酸酯类、阿司匹林、他汀类调脂、β受体拮抗剂和钙离子拮抗剂等常规治疗药物。麝香保心丸组在对照组基础上加用麝香保心丸口服(2丸,每日3次),前列地尔组在麝香保心丸治疗组基础上加用前列地尔注射液(10μg,静脉滴注,每日1次)。治疗10 d后观察三组临床、心电图疗效。结果前列地尔组临床疗效总有效率(95.0%)高于麝香保心丸组(80.0%)及对照组(57.5%),差异有统计学意义(P<0.05)。前列地尔组心电图疗效总有效率(82.5%)高于麝香保心丸组(60.0%)及对照组(40.0%),差异有统计学意义(P<0.05)。结论前列地尔联合麝香保心丸治疗心绞痛疗效好。

Objective To observe the therapeutic effect of Alprostadil Injection combined with Shexiang Baoxin Wan on angina pectoris. Methods 120 patients with angina pectoris were randomly divided into 3 groups with random sing/e-blind contrast method. The patients in control group （38 cases） were given conventional treatment including Aspirin, statins tune ester, 13 receptor antagonists and calcium channel blockers. The patients in Shexiang Baoxin Wan group （42 cases） were giv- en Shexiang Baoxin Wan per os （2 pills, three times a day） in addition to the conventional treatment. The patients in A1- prostadil group were given Alprostadil （10 ~g intravenous push, one time a day）. The patients in 3 groups were observed for 15 days to check the efficacy of treatment and ECG changes. The clinical effects and ECG curatives were recorded after treatment for 15 days. Results The clinical total effective rate in Alprostadil group （95.0%） was higher than those of Shexi- ang Baoxin Wan group （80.0%） and control group （57.5%）, the difference was significant （P 〈 0.05）. The total effective rate of ECG in Alprostadil group （82.5%） was higher than that of Shexiang Baoxin Wan group （60.0%） and the control group （40.0%）. The difference was significant among the three groups （P 〈 0.05）. Conclusion Alprostadil therapy combined with Shexiang Baoxin Wan has a better curative effect on angina pectoris.