小柴胡汤合升降散在慢性乙型肝炎中的疗效观察

Observation on the effect of Xiao Chaihu Decoction combined with Shengjiang Powder in the treatment of chronic hepatitis B

目的探讨小柴胡汤合升降散在慢性乙型肝炎中的疗效。方法选取2008年1月~2011年1月84例慢性乙型肝炎患者,将其随机分为对照组（西医治疗组）42例和观察组（小柴胡汤合升降散组）42例,对两组总有效率、不良反应发生率、治疗前后的血流动力学、免疫球蛋白及其补体水平进行统计及比较。结果观察组临床总有效率（97.62%）高于对照组（88.09%）,不良反应发生率（0）低于对照组（14.28%）,血流动力学[门静脉内径（1.07±0.08）cm、门静脉血流速度（17.02±1.72）cm/s、门静脉血流量（881.43±125.70）mL/min]、免疫球蛋白及其补体[IgA（2.70±0.23）g/L、IgG（10.52±1.23）g/L、IgM（0.91±0.14）g/L、C3（1.39±0.18）g/L、C4（0.30±0.04）g/L]均优于对照组[门静脉内径（1.18±0.10）cm、门静脉血流速度（15.43±1.68）cm/s、门静脉血流量（921.33±117.86）mL/min、IgA（3.02±0.20）g/L、IgG（11.98±1.20）g/L、IgM（0.80±0.15）g/L、C3（0.93±0.15）g/L、C4（0.22±0.04）g/L],差异均有统计学意义（均P〈0.05）。结论小柴胡汤合升降散在慢性乙型肝炎中的疗效好,安全性高,对于患者的免疫状态及肝脏状态的改善有积极的作用。

Objective To study the effect of Xiao Chaihu Decoction combined with Shengjiang Powder in the treatment of chronic hepatitis B.Methods 84 patients with chronic hepatitis B from January 2008 to January 2011 were selected as research objects,and they were randomly divided into control group（Western medicine therapy group） with 42 cases and observation group（Xiao Chaihu Decoction combined with Shengjiang Powder group） with 42 cases,and the total effect rate,incidence of adverse reactions,hemodynamics indexes,immunoglobulin level and its complement before and after the treatment of two groups were analyzed and compared.Results The total effect rate of observation group（97.62%） was higher than that（88.09%） of control group,incidence of adverse reactions（0） was lower than that（14.28%） of control group,haemodynamics indexes [diameter of portal vein（1.07±0.08）cm,blood flow velocity of portal vein（17.02±1.72）cm/s,blood flow of portal vein（881.43±125.70）mL/min],immunoglobulin level and its complement [IgA（2.70±0.23）g/L,IgG（10.52±1.23）g/L,IgM（0.91±0.14）g/L,C3（1.39±0.18）g/L,C4（0.30±0.04）g/L] were all better than those of control group [diameter of portal vein（1.18±0.10）cm,blood flow velocity of portal vein（15.43±1.68）cm/s,blood flow of portal vein（921.33±117.86）mL/min,IgA（3.02±0.20）g/L,IgG（11.98±1.20）g/L,IgM（0.80±0.15）g/L,C3（0.93±0.15）g/L,C4（0.22±0.04）g/L],there were significant differences（all P 0.05）.Conclusion The effect of Xiao Chaihu Decoction combined wtih Shengjiang Powder in the treatment of chronic hepatitis B is better,security is higher,and it plays an active role in improving state of immune and liver of patients.