血清前列腺特异性抗原、游离前列腺特异性抗原水平与前列腺增生症相关性探讨

Study of the relationship between different serum prostate specific antigen,free PSA levels and benign prostatic hyperplasia

目的研究血清前列腺特异性抗原(PSA)、游离前列腺特异性抗原(fPSA)与前列腺增生症(BPH)之间的临床相关性,探讨PSA水平升高的相关因素。方法回顾性分析112例BPH手术患者的临床资料,对血清PSA、fPSA与BPH患者的年龄、前列腺体积(PV)、国际前列腺症状评分(IPSS)、生活质量评分(QOL)等进行相关性分析。结果PSA<4μg/L 48例(42.9%),PSA 4～10μg/L 41例(36.6%),PSA>10μg/L 23例(20.5%),血清PSA、fPSA水平与年龄、PV、IPSS均呈正相关关系(r=0.31、0.57、0.20;0.36、0.63、0.22,均P<0.05),并且与血清PSA相比,fPSA与PV的相关性更强。血清PSA、fPSA水平与QOL评分无相关性(r=0.14、0.17,均P>0.05)。结论前列腺体积增大、高龄和高IPSS评分是接受手术治疗BPH患者血清PSA、fPSA升高的主要相关因素。

Objective To study of relationship between serum PSA,free PSA levels and benign prostatic hyperplasia（BPH）,and the correlated factors about the serum PSA in the BPH patients.Methods A total of 112 inpatients with BPH who had received operation were analyzed retrospectively.The PSA,free PSA,patient age,prostate volume,IPSS and QOL score were analyzed.Results The levels of serum PSA in 48 cases（42.9%） were less than 4 μg/L,41 cases（36.6%） were 4-10 μg/L,and 23 cases（20.5%） were over 10 μg/L.The serum PSA,free PSA level and patient age,prostate volume,IPSS were positively correlated（r = 0.31,0.57,0.20;0.36,0.63,0.22,all P 0.05）,and the serum free PSA compared to the PSA showed a stronger relationship with PV.The serum PSA,free PSA level and QOL score did not have correlated（r = 0.14,0.17,all P 0.05）.Conclusion Among these related factors affecting serum PSA and free PSA levels,the enlarged prostate volume,high age and high IPSS score are considered to be the main correlation factors.