P53蛋白在胃癌中的表达分析

Analysis on expression of positive rate of P53 protein in patients with gastric cancer

目的探讨P53蛋白在胃癌中的表达。方法胃癌患者53例作为A组,胃炎患者53例作为B组,健康人士53例作为C组,均采用免疫组织化学法(S-P)检测P53阳性率。结果 A组P53阳性率为64.2%,B组为32.1%,C组为13.2%,组间比较差异有统计学意义(A、B:χ2=9.674,P<0.01;A、C:χ2=26.888,P<0.01;B、C:χ2=4.363,P<0.05)。A组高分化癌P53阳性率为78.6%,低分化癌为48.0%,两者比较差异有统计学意义(χ2=4.120,P<0.05)。B组浅表性胃炎P53阳性率为40.0%,萎缩性胃炎为21.7%,萎缩性胃炎P53阳性率高于浅表性胃炎,但差异无统计学意义(χ2=1.243,P>0.05)。结论对胃病患者进行P53的早期检测,对监测病情和改善预后具有重要意义,值得临床考虑。

Objective To study the expression of positive rate of P53 protein in patients with gastric cancer.Methods 53 cases of patients with gastric cancer as group A,53 cases of patients with gastritis as group B and 53 cases of healthy person as group C were all given detection of positive rate of P53 by S-P method.Results The positive rate of P53 in group A was 78.6%;group B was 48.0%;group C was 13.2%.There were significant difference＇s between each group（A,B： χ2=9.674,P0.01;A,C： χ2=26.888,P0.01;B,C： χ2=4.363,P0.05）.The positive rate of P53 in group A of differentiated carcinoma was 78.6%;poor differentiated carcinoma was 48.0%.The comparison between the two showed significant difference（χ2=4.120,P0.05）.The positive rate of P53 in group B of superficial gastritis was 40.0%;atrophic gastritis was 21.7%.The superficial gastritis was higher,but no significant difference（χ2=1.243,P 0.05）.Conclusion Detection of P53 of patients with gastropathy at early stage is very important on monitoring disease and changing prognosis,so it deserves considering in clinical work.