乌司他丁在预防不同胃肠术后吻合口瘘中的效果观察

Observation of curative effect on Ulinastain in preventing anastomotic leakage after different gastrointestinal operations

目的探讨乌司他丁在预防不同胃肠术后吻合口瘘中的效果。方法选取2005年6月～2011年8月于本院进行胃肠术进行治疗的220例患者为研究对象,将其随机分为对照组和观察组各110例,观察组在对照组的基础上加用乌司他丁,后将两组患者中不同术式的吻合口瘘发生率及术前、术后1 d及3 d的血清超敏C反应蛋白(hs-CRP)、白介素2(IL-2)、白介素6(IL-6)、肿瘤坏死因子α(TNF-α)、血液流变学指标进行统计及比较。结果观察组不同术式的吻合口瘘发生率及总发生率均低于对照组,血清hs-CRP、IL-6、TNF-α水平低于对照组,IL-2高于对照组,血液流变学指标改变幅度小于对照组,差异均有统计学意义(均P<0.05)。结论乌司他丁可以改善胃肠手术患者的炎性状态及血液循环情况,对于降低吻合口瘘的发生率有着积极的作用。

Objective To study the effect of Ulinastain in preventing anastomotic leakage after different gastrointestinal operation.Methods 220 patients treated with gastrointestinal operation in our hospital from June 2005 to August 2011 were selected as research object,and they were randomly divided into control group and observation group with 110 cases in each group,then the anastomotic leakage rate of different gastrointestinal operation and serum high-sensitivity C-reactive protein（hs-CRP）,interleukin 2（IL-2）,interleukin 6（IL-6）,tumor necrosis factor α（TNF-α）,hemorheology indexes before and after the operation at first and third day of two groups were analyzed and compared.Results The anastomotic leakage rate of different gastrointestinal operation and total rate of observation group were all lower than those of control group,serum hs-CRP,IL-2,TNF-α and IL-6 after the operation at first and third day were lower than those of control group,IL-2 were higher than those of control group,change range of hemorheology indexes were smaller than those of control group,there were significant differences（all P 〈0.05）.Conclusion Ulinastain can improve the inflammation state and blood circulation state of gastrointestinal operation,and it plays an active role in reducing the incidence of anastomotic leakage.