高危型HPV监测在宫颈上皮内瘤变Ⅰ随访中的意义

Significance of high risk human papillomavirus monitoring in follow-up of cervical intraepithelial neoplasia Ⅰ

目的:探讨HR-HPV监测在宫颈上皮内瘤变I级(CINI)随访中的意义。方法:对158例CINI级患者每8个月随访1次,共2年。随访内容为采用HC-2检测技术检测HR-HPV感染、宫颈细胞学检查,异常者行阴道镜检查及活检,随访终点为病理诊断为CINII、CINIII及宫颈癌(此3项定义为CINII+)。结果:57例HR-HPV阴性者及63例一过性HR-HPV者中无一例病变进展;38例持续性HR-HPV感染者17例病变进展,3组间病变进展率之间有统计学差异(P<0.05),病毒负荷量与病变进展无相关性(P>0.05)。结论:持续性HR-HPV感染者CINI病变进展率高,应密切随访或采用手术治疗。

Objective：To explore the significance of high risk human papillomavirus（HPV） monitoring in follow-up of cervical intraepithelial neoplasia（CIN） Ⅰ.Methods：One hundred and fifty-eight patients with CIN Ⅰ were followed up every eight months for two years.The contents of follow-up included high risk HPV infection detected by hybrid capture II technique,cervical cytological examination,the patients with abnormal results underwent colposcopy and biopsy,the endpoint of follow-up was CIN Ⅱ,CIN Ⅲ,and cervical cancer（the three diseases were designed as CIN Ⅱ＋）.Results：Among 57 patients with negative high risk HPV and 63 patients with transient high risk HPV,one patient was found with aggravation of the disease;among 38 patients with continuous high risk HPV infection,17 patients were found with aggravation of the disease,there was significant difference in the aggravation rate among the three groups（P0.05）.There was no correlation between viral load and the aggravation of the disease（P0.05）.Conclusion：The aggravation rate of CIN among the patients with continuous high risk HPV infection is high,close follow-up or surgery should be performed.