宫腔内配子移植治疗黄素化未破裂卵泡综合征所致不孕症疗效观察

Observation on the curative effect of gamete intrauterine transfer in treatment of infertility induced by luteinizing unruptured follicle syndrome

目的:观察宫腔内胚子移植(GIUT)治疗黄素化未破裂卵泡综合征(LUFS)所致不孕症的临床疗效。方法:对23例LUFS所致不孕症患者进行36个周期的GIUT,采用自然周期或小剂量氯米芬微刺激方案促排卵,阴道B超监测卵泡的生长情况,当有1个以上卵泡直径≥18或2个以上卵泡直径≥16时肌内注射人绒毛膜促性腺激素(HCG)5 000 IU,24～36 h内取卵实施宫腔内胚子移植。结果:36个周期GIUT中,临床妊娠7例,周期妊娠率19.44%,生化妊娠1例,36个周期中未发生宫外孕、双胎妊娠及卵巢过度刺激综合征(OHSS)。结论:GIUT治疗卵泡未破裂黄素化综合征所致不孕症有一定疗效,且程序简化,价格低,值得基层推广应用。

Objective：To observe the curative effect of gamete intrauterine transfer（GIUT） in treatment of infertility induced by luteinizing unruptured follicle syndrome（LUFS）.Methods：Twenty three patients with infertility induced by LUFS received GIUT（36 cycles）,natural cycle or low-dose clomiphene microstimulation protocol was used for ovulation induction,transvaginal B ultrasonography was used to monitor the growth of follicles;when the follicular diameter of more than one follicle≥18 mm,or the follicular diameter of more than two follicles≥16 mm,the patients were treated with intramuscular injection of human chorionic gonadotropin（HCG） 5 000 IU;at 24-26 hours after HCG administration,GIUT was performed.Results：After GIUT for 36 cycles,seven patients got clinical pregnancy,the clinical pregnancy rate was 19.44%,one patient got biochemical pregnancy,no ectopic pregnancy,twin pregnancy,and ovarian hyperstimulation syndrome（OHSS） occurred during 36 cycles.Conclusion：GIUT has a certain curative effect in treatment of LUFS,which is simple and inexpensive,and the method is worthy to be popularized in primary hospitals.