期刊文献+

大环内酯类抗生素抗菌机制及构效关系研究现状 被引量:3

Current Research Status of Antibacterial Mechanisms and Structure-activity Relationships of Macrolide Antibiotics
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摘要 大环内酯类抗生素在临床上的广泛应用导致其耐药性问题日益凸显,对其作用机制及构效关系进行深入研究,有助于设计出抗菌活性更强且不易诱导耐药性的新型抗生素。综述大环内酯类抗生素抗菌机制及构效关系的研究现状。 The wide use of macrolide antibiotics in clinical practice has led to the increasing drug resistance problems in bacteria. Making deep research on the action mechanisms and structure-activity relationships (SARs) of macrolides is helpful to the rational design for the new antibiotics which can overcome bacterial resistance and improve the anti-bacteria activities. The current research status of antibacterial mechanisms and SARs of macrolide antibiotics was reviewed in this paper.
出处 《药学进展》 CAS 2012年第2期49-56,共8页 Progress in Pharmaceutical Sciences
关键词 红霉素 大环内酯 抗菌机制 构效关系 耐药性 erythromycin macrolide antibacterial mechanism structure-activity relationship drug resistance
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参考文献27

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同被引文献35

  • 1张小敏,于蕾,贺春朋,季宇彬.抗肿瘤生物碱的构效关系[J].中草药,2009,40(S1):58-60. 被引量:1
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