胺碘酮联合硫酸镁治疗顽固性室性心律失常的疗效与安全性

Effects and safety of amiodarone combined with magnesium sulfate in patients with refractory premature ventricular contractions

目的评价胺碘酮片联合硫酸镁静滴治疗顽固性室性心律失常的临床疗效及安全性。方法 45例患者随机分为2组,治疗组口服胺碘酮片0.2 g,每日3次,2周后减量,同时静滴25%硫酸镁注射液2.0 g,每日1次,共7天。对照组只口服胺碘酮片,剂量、方法同治疗组,2周为一个疗程。观察治疗前后室性早搏、心脏功能及药物不良反应。结果治疗后,治疗组与对照组24 h室性早搏发作总次数、短阵性室性心动过速阵次均有显著变化,治疗组明显优于对照组(P<0.01);心功能改善,治疗组也明显好于对照组(P<0.05)。2组各有1例出现心动过缓。结论胺碘酮和硫酸镁联合应用治疗顽固性室性心律失常疗效好且安全。

Objective To observe the effects and safety of amiodarone combined with magnesium sulfate in patients with refractory premature ventricular contractions.Methods Forty-five patients were randomly divided into two groups.Treatment group： oral amiodarone,0.2 g,three times a day for two weeks and 2.0 g（25%） of magnesium sulfate was diluted in 5% glucose or 0.9% sodium chloride solution 250 mL,once a day,intravenous drip for 7 days.The control group： only oral amiodarone,0.2 g,three times a day for two weeks.The ventricular premature beats,heart function and side effects were observed after two weeks.Results The decrease of number of refractory premature ventricular contractions and times of temporal ventricular tachycardia as well as improvement of heart function in the treatment group were better than in the control group（P0.05）.No side-effect was occurred except for one patient with bradycardia in each group.Conclusion It is effective and safe in treating refractory premature ventricular contractions by oral amiodarone with magnesium sulfate injection.