期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

非甾体抗炎药研究的最新进展 被引量：28

Recent Research Advances of Nonsteroidal Anti-Inflammatory Drugs(NSAIDs)
原文传递
导出
摘要 非甾体抗炎药(NSAIDs)是一类广泛用于抗炎、解热、镇痛的药物,但由于胃肠道毒副作用和肾毒性使它的应用受到很大限制。因此研制出能降低传统NSAIDs副作用且具良好活性的新型NSAIDs成为这类药物发展的主要方向,如选择性环氧化酶-2(COX-2)抑制剂、一氧化氮释放型NSAIDs、环氧化酶/脂氧合酶(COX/LOX)双重抑制剂、脂蛋白磷脂酶A2(LP-PLA2)抑制剂、前列腺素E2合成酶-1(mPGES-1)抑制剂以及肿瘤坏死因子-α(TNF-α)抑制剂等。本文从这几个方面对NSAIDs最新研究进行了简要介绍。 Nonsteroidal anti-inflammatory drugs（NSAIDs） are a class of widely prescribed drugs for the use of anti-inflammatory,antipyretic and analgesic,but their application have been restricted for their gastrointestinal side effects and renal toxicity.Therefore,to develop novel NSAIDs with lower side effects and excellent activity,compared with the traditional NSAIDs,becomes the main direction of these drugs development.Emerging trends are represented by selective cyclooxygenase-2（COX-2） inhibitors,nitric oxide-release NSAIDs,dual COX/lipoxygenase（LOX） inhibitors,lipoprotein phospholipase A2（LP-PLA2） inhibitor,prostaglandin E2 synthase-1（mPGES-1） inhibitors,tumor necrosis factor-α（TNF-α） inhibitors and so on.In this paper,the latest research on NSAIDs has been briefly introduced from these several aspects.
作者 戴海霞 张晓燕 徐开俊 陈建华
机构地区 中国药科大学物理化学教研室 日照市人民医院眼科 中国药科大学分子生物学教研室
出处 《药物生物技术》 CAS CSCD 2012年第1期90-94,共5页 Pharmaceutical Biotechnology
关键词 非甾体抗炎药 脂蛋白磷脂酶A2 前列腺素E2合成酶-1 肿瘤坏死因子-Α NSAIDs Lp-PLA2 mPGES-1 TNF-α
分类号 R9 [医药卫生—药学]
  • 相关文献

参考文献29

  • 1Inotai A, Hanko B, Meszaros A. inflammatory drug market in Trends in the non-steroidal anti six Central-Eastern European countries based on retail information [J]. Pharmacoepidemiol Drug Saf,2010,19(2 ) : 183.
  • 2Muller N. COX-2 inhibitors as antidepressants and antipsychotics : Clinical evidence[ J]. Curr Opin Invest Drugs,2010,11:31.
  • 3Rao PNP, Rajesh KG. Apricoxib, a COX-2 inhibitor for the potential treatment of pain and cancer [ J ]. I Drugs, 2009, 12 (11) :711.
  • 4Biava M, Porretta GC, Poce G, et al. Novel ester and acid derivatives of the 1,5-diarylpyrrole scaffold as anti-inflammatory and analgesic agents. Synthesis and in vitro and in vivo biological evaluation [J]. J Med Chem,2010 ,53 (2) :723.
  • 5Renard JF, Arslan D, Garbaeki N, et al. Pyridine analogues of nimesulide : design, synthesis, and in vitro and in vivo pharmacological evaluation as promising cyclooxygenase 1 and 2 inhibitors [ J ]. J Med Chem, 2009,52 ( 19 ) :5864.
  • 6Wallace JL, Ignarro LJ, Fiorucci S. Potential eardioprotective actions of no-releasing aspirin [ J ]. Nat Rev Drug Discov, 2002,1(5) :375.
  • 7Velazquez CA, Chen QH, Citro ML, et aL Second-generation aspirin and indomethacin prodrugs possessing an 0 ( 2 ) -( acetoxymethyl) -1 -( 2-carboxypyrrolidin-1 -yl ) diazenium-1,2-diolate nitric oxide donor moiety : design, synthesis, biological evaluation, and nitric oxide release studies [ J ]. J Med Chem, 2008, 51 (6) :1954.
  • 8Lazzarato L, Donnola M, Rolando B, et al. ( Nitrooxyacyloxy ) methyl esters of aspirin as novel nitric oxide releasing aspirins [ J ]. J Med Chem,2009,52 ( 16 ) : 5058.
  • 9Dailey LA, Imming P. 12-Lipoxygenase : classification, possible therapeutic benefits from inhibition, and inhibitors [ J ]. Curt Med Chem, 1999,6 ( 5 ) : 389.
  • 10Reddy MV, Billa VK, Pallela VR, et al. Design, synthesis, and biological evaluation of 1-( 4-sulfamylphenyl ) -3-trifluoromethyl-5indolyl pyrazolines as cyclooxygenase-2 ( COX-2 ) and lipoxygenase (LOX) inhibitors [ J 1. Bioorg Med Chem, 2008, 16 (7) :3907.

同被引文献250

引证文献28

二级引证文献248

药物生物技术
2012年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部