去乙酰化酶SIRT1及其对细胞凋亡调控的研究进展

Recent Advances of Deacetylase SIRT1 on Apoptosis Regulation

细胞凋亡在机体生理功能中起着重要作用,是机体清除体内损伤、衰老及具有潜在威胁性细胞的一种基本方式。沉默信息调节因子2相关酶1(silent information regulator 2homolog 1,SIRT1)作为哺乳动物Sirtuin家族的一员,自发现以来作为重要的调控因子被广泛研究;最近研究报道SIRT1调控一系列转录因子如p53、FOXO家族和NF-κB,在细胞凋亡中起关键的作用。作者主要阐述了SIRT1的分子生物学特性、表达调控及SIRT1与细胞凋亡的关系。

Apoptosis plays an important role in physiological functions in organisms.It＇s an essential way to get rid of damaged,senescent,potentially harmful cells in organisms.Silent information regulator 2 homolog 1（SIRT1） is a member of the mammalian sirtuins,which is widly researched as an important regulatory factor ever since discoveried.Recent studies indicate that SIRT1 targets a wide range of transcriptional regulators including protein 53（p53）,forkhead box class O（FOXO） proteins and nuclear factor-κB（NF-κB）,which suggests SIRT1 may has capital effects in apoptosis.This review introduced the molecular biology feature of SIRT1,expression regulation and the relationship between SIRT1 and apoptosis.