氟比洛芬酯用于上腹部术后镇痛的疗效及安全性观察

Therapeutic efficacy and safety of intravenous flurbiprofen axetil for analgesia after upper abdominal surgery

目的观察上腹部术后患者PCIA中,氟比洛芬酯镇痛效果与不良反应,及对凝血功能的影响。方法选择行上腹部手术患者90例均分为3组,A组术后镇痛给予舒芬太尼200μg稀释到盐水100 mL;B组关腹前静脉注射氟比洛芬酯50mg,术后镇痛给予舒芬太尼200μg稀释到盐水100 mL;C组关腹前静脉注射氟比洛芬酯50 mg,术后镇痛给予舒芬太尼200μg+氟比洛芬酯100 mg稀释到盐水100 mL。3组PCIA泵的设置维持量1.2 mL/h,单次负荷剂量1.2 mL,锁定时间20 min。观察3组术后24 h、48 h的镇痛评分(VAS评分)和不良反应的发生情况。结果 3组镇痛效果均满意,而B组恶心,呕吐等药物不良反应发生率低于A、C组。B、C两组舒芬太尼用量及患者按压次数均低于A组。结论氟比洛芬酯联合舒芬太尼用于上腹部术后的镇痛效果与单纯舒芬太尼相似,但不良反应降低。

Objective To observe and evaluate the analgestic efficacy of flurbiprofen axetil and its effect on coagulatioin function in patients with upper abdominal surgery.Methods Ninety patients suffered from upper abdominal surgery were divided equally and randomly into 3 groups.Group A was given sufentanyl 200 μg dissolved in 100 mL saline for PCIA after surgery.Group B was administrated with flurbiprofen axetil 50 mg before thorax closure,and sufentanyl 200 μg dissolved in 100 mL for PCIA after surgery.Group C was given flurbiprofen axetil 50 mg before thorax closure and flurbiprofen axetil 100 mg plus sufentanyl 200 μg dissolved in 100 mL saline for PCIA after surgery.The volume for PCIA was 1.2 mL/h,blous 1.2 mL,lock time 20 min.VAS scales and side effects were evaluated 24 h and 48 h after surgery.Results There was no significant difference in analgesia grade among three groups.The side effects were lower in group B than those in group A and group C.Conclusion Compared with sufentany1 alone,flurbiprofen axetil combined with sufentanyl can obtain similar analgesic effects,but can reduce side effects.