慢性阻塞性肺病急性加重患者前白蛋白及C反应蛋白变化及临床意义

Changes and clinical significance of serum prealbumin and C-reactive protein in patients with acute exacerbation of chronic obstructive pulmonary disease

目的探讨慢性阻塞性肺病(COPD)急性加重患者治疗前后血前白蛋白(PA)、C反应蛋白(CRP)的变化及临床意义。方法选择COPD急性加重住院患者78例,分别测定入院时及病情缓解后稳定期的血PA和CRP,并与健康对照组比较。结果 COPD患者急性加重期较稳定期PA明显下降,并且均较对照组明显降低,CRP明显升高,差异有统计学意义。结论血清PA、CRP可作为评估COPD患者急性加重期病情控制的指标。

Objective To investigate the changes of serum prealbumin（PA） and C-reactive protein（CRP） and their clinical significance in patients with acute exacerbation of chronic obstructive pulmonary disease（COPD） after treatment.Methods The levels of serum PA and CRP in 78 cases with acute exacerbation of COPD admitted to hospital before and after treatment were detected and analyzed.The changes of the controls were compared.Results The levels of serum PA of patients with acute exacerbation of COPD were significantly lower than those in remission,those both before and after treatment were lower than those in the controls.The levels of serum CRP increased significantly.There were significant differences.Conclusion Serum PA and CRP can be used to evaluate the severity of patients with acute exacerbation of COPD.