抗抑郁药对带状疱疹后神经痛疗效影响的随机对照研究

EFFICACY OF ANTIDEPRESSANT IN THE TREATMENT OF POSTHERPETIC NEURALGIA:A PROSPECTIVE,RANDOMIZED,CONTROLLED STUDY

目的:评估抗抑郁药治疗带状疱疹后神经痛的疗效。方法:90例带状疱疹后神经痛患者随机分为对照组(n=47)和试验组(n=43)。对照组采用常规疗法包括:药物治疗、物理治疗和微创治疗等。试验组在对照组的基础上加用抗抑郁药帕罗西汀20 mg,每天一次。采用视觉模拟评分法(visual an-alogue scale,VAS)分别于治疗前和治疗第30天评估疼痛强度,并计算疼痛缓解率。结果:两组治疗后比治疗前疼痛强度均显著降低(P<0.05),治疗后组间比较,试验组疼痛缓解率显著高于对照组(P<0.05)。结论:抗抑郁药帕罗西汀可有效提高带状疱疹后神经痛的疗效。

Objective：To evaluate the efficacy of antidepressant in the treatment of postherpetic neuralgia（PHN）.Metheds： 90 PHN patients were randomized into control group（n = 47）（conventional therapies such as anticonvulsants,opioids,nerve blockade,superlaser and so on） and paroxetine-treatment group（n = 43）（conventional therapies plus paroxetine 20 mg,qd）.Pain intensity was evaluated with visual analogue scale（VAS） before and 30 days after treatment.Results： Compared with before treatment,the intensity of PHN patients decreased after treatment in both group（P 0.05）.The remission rate of pain intensity in paroxetine-treated group was higher than that in control group（P 0.05）.No serious paroxetine-related adverse effects were found.Conclusion： Antidepressant can improve the efficacy of conventional therapies in the treatment of PHN.