内蒙古产白刺、小果白刺和霸王α-葡萄糖苷酶抑制活性

α-Glucosidase Inhibitory Activitives of S.xanthoxylon Bunge,N.tangutorum Bobr and N.sibirica Pall,grown in Neimenggu from Zygophyllaceae

首次利用体外α-葡萄糖苷酶抑制模型对内蒙古产3种蒺藜科植物的9个提取物进行活性评价,并与阳性对照Acarbose比较,发现3种植物均有抑制α-葡萄糖苷酶活性。其中白刺石油醚提取物对α-葡萄糖苷酶的抑制活性(IC50=81.80 mg/L)最高,其余依次为小果白刺乙酸乙酯提取物(IC50=610.29 mg/L),霸王石油醚(IC50=627.22 mg/L)和乙酸乙酯提取物(IC50=838.40 mg/L),它们的抑制活性远大于阳性对照Acarbose(IC50=1103.01 mg/L)。结果发现,不同植物不同溶剂提取物的α-葡萄糖苷酶抑制活性不同。同一植物不同溶剂提取物相比较,甲醇提取物的α-葡萄糖苷酶抑制活性不及乙酸乙酯和石油醚提取物。

The α-glucosidase inhibitory activities of nine extracts from three species of Zygophyllaceae in Neimenggu were evaluated in vitro by 96-microplate-based method for the first time.All these three species showed α-glucosidase inhibitory activities compared with the positive control ＂acarbose＂.Among these nine extracts,petroleum ether extract of Nitraria tangutorum Bobr.had the highest inhibitory activity（IC50=81.80 mg/L）,followed by the ethyl acetate extract of N.sibirica Pall（IC50=610.29 mg/L）,the petroleum ether extract（IC50 =627.22 mg/L） and ethyl acetate extract（IC50=838.40 mg/L） of Sarcozygium xanthoxylon Bunge,all of which are much higher than that of acarbose（IC50=1103.01 mg/mL）.Different extracts of different plants showed different inhibitory activies,while the inhibitory activity of different extracts from the same plant varied a lot.The methanolic extract had lower inhibitory activity than that of ethyl acetate extract and petroleum ether extract.