磷霉素银的制备及其体外抑菌试验

Preparation and Anti microbial activities in vitro of Phosphonomycin silver

目的：制备磷霉素银并测定其抑菌活性。方法：采用复分解法制备磷霉素银，并经体外抑菌试验比较了磷霉素银与磺胺嘧啶银和磷霉素钙的抗菌活性。结果：磷霉素银的各剂量组抑菌圈均大于磷霉素钙和磺胺嘧啶银。结论：磷霉素银的抗菌作用强于磷霉素钙和磺胺嘧啶银。

Aim In order to prepare Phosphonomycin silver and evaluate its anti-microbial activities in vitro.Methods Double decomposition reaction was used to prepare phosphonomycin silver and disc agar diffusion test was used to compare the anti-microbial activities of phosphonomycin silver with those of sulfadiazine silver and calcium phosphonomycin.Result The inhibitory zone of phosphonomycin silver was larger than that of sulfadiazine silver and calcium phosphonomycin.Conclusion Phosphonomycin silver exhibited more potent anti-microbial activities against Escherichia coli, Staphylococcus aureus and pseudomonas aeruginosa than sulfadiazine silver and calcium phosphonomycin.