子宫腺肌病组织中MCP-1含量变化及意义

Changes of monocyte chemoattractant protein-1 content in adenomyotic tissue and its significance

目的探讨单核细胞趋化蛋白-1(monocyte chemoattractant protein-1,MCP-1)在子宫腺肌病发病中的作用。方法采用免疫组化法和实时荧光定量PCR法检测36例子宫腺肌病患者在位内膜、异位病灶组织中的MCP-1含量,并与相应对照组进行比较。结果腺肌病患者在位内膜和异位病灶组织MCP-1含量均高于相应正常对照组(P<0.05);异位病灶组织中MCP-1含量高于在位内膜(P<0.05),且两者具有相关性(r=0.87,P<0.01)。结论 MCP-1可能参与了子宫腺肌病的发病过程,但具体分子机制尚需进一步研究。

Objective To investigate the role of monocyte chemoattractant protein-1（MCP-1） in the pathogenesis of adenomyosis.Methods MCP-1 was examined by immunohistochemistry method and real-time PCR in the eutopic endometrium and ectopic endometrium of 36 patients with adenomyosis,and the results were compared with those of controls.Results MCP-1 contents in the eutopic endometrium and ectopic endometrium of patients with adenomyosis were significantly higher than those of normal controls（P0.05）.The contents in ectopic endometrium tissue was significantly higher than that in eutopic endometrium tissue（P0.05）,and the contents in the two tissues were significantly correlated with each other（r=0.87,P0.01）. Conclusion MCP-1 may be involved in the pathogenesis of adenomyosis,but the specific molecular mechanisms need further study.