破骨细胞伪足小体的结构和功能

Structure and Functions of Podosome in Osteoclast

破骨细胞是一种由造血干细胞分化而来的具有骨吸收功能的多核细胞。破骨细胞的骨吸收功能与其肌动蛋白骨架的完整性有关。研究表明,破骨细胞肌动蛋白骨架的基本结构为伪足小体(podosome)。在破骨细胞分化的不同阶段,伪足小体呈现不同的形态结构。伪足小体的形成过程及结构完整性直接影响着破骨细胞的分化及其骨吸收活性。深入研究伪足小体的结构和功能可为探索破骨细胞的骨吸收机制和寻找骨骼疾病药物作用靶点提供新的思路。该文将围绕破骨细胞伪足小体的结构、功能及其调节机制进行综述。

Osteoclasts,multinucleated cell derived from hemopoietic stem cell,have bone absorption function which related to the integrality of F-actin.Studies demonstrated that podosome is the basic structure of F-actin in osteoclast.There are different patterns of podosome in the process of osteoclast differentiation.The forming process and integrality of podosome play crucial roles in the differentiation and bone absorption of osteoclast.Researches on podosome are helpful to understand the mechanism of bone resorption and to develop new therapeutics on bone diseases.In this paper,the structure,functions and the regulation mechanism of podosome were summarized.