海洛因依赖者血液流变学及血脂变化的研究

Study of the hemorheology characteristics and blood lipid in the heroin addicts

目的:探讨海洛因依赖者血液流变学及血脂的变化,防止并发症的发生。方法:收集70例海洛因依赖者和75例健康体检者血液测定血液流变学、血脂等指标,并进行比较分析。结果:海洛因依赖者全血粘度、血浆粘度、红细胞聚集指数、纤维蛋白原、甘油三酯、脂蛋白a等指标显著增高(P<0.05);血清胆固醇、高密度脂蛋白胆固醇、红细胞变性指数、红细胞刚性指数及红细胞压积等指标低于正常对照组(P<0.05)。结论:海洛因依赖者存在明显的脂代谢紊乱和血液流变学指标异常,应定期进行血脂、血流变检测,预防心脑血管疾病等并发症的发生。

Objective： To study the changes of the hemorheology characteristics and blood lipid in the heroin addicts and prevents complication. Methods： 70 heroin addicts were selected, 75 normal persons were also selected as control. There hemorheology characteristics and blood lipid were measured. Results： Compared with the control, the whole blood viscosity （ high shear, middle shear, low shear）, plasma viscosity, RBC aggregation fibrinogen, triglycerides were significantly higher in the heroin addicts （ P 〈 0. 05 ） ; the level of total cholesterol, high-density lipoprotein cholesterol, RBC stiffness index, RBC distortion and HCT were significantly lower （ P 〈 0. 05）. Conclusion： The hemorheology characteristics and blood lipid was abnormal in the heroin addicts, on a regular basis hemorheology and blood lipid testing, the prevention of cardiovascular and cerebrovascular complications have happened.