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MicroRNAs and Type 2 Diabetes/Obesity 被引量：21

MicroRNAs and Type 2 Diabetes/Obesity
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摘要 MicroRNAs belong to a newly identified class of small non-coding RNAs that have been widely implicated in the fine-tuning of many physiological processes such as the pathogenesis of type 2 diabetes （T2D） and obesity. Microarray studies have highlighted an altered profile of miRNA expression in insulin target tissues in diabetic and obese models. Emerging evidences suggest that miRNAs play significant roles in insulin production, secretion and actions, as well as in diverse aspects of glucose homeostasis and adipocyte differentiation. The identification of tissue-specific miRNAs implicated in T2D and obesity might be useful for the future development of effective strategies for early diagnosis and therapeutic intervention of obesity-related medical complications. MicroRNAs belong to a newly identified class of small non-coding RNAs that have been widely implicated in the fine-tuning of many physiological processes such as the pathogenesis of type 2 diabetes （T2D） and obesity. Microarray studies have highlighted an altered profile of miRNA expression in insulin target tissues in diabetic and obese models. Emerging evidences suggest that miRNAs play significant roles in insulin production, secretion and actions, as well as in diverse aspects of glucose homeostasis and adipocyte differentiation. The identification of tissue-specific miRNAs implicated in T2D and obesity might be useful for the future development of effective strategies for early diagnosis and therapeutic intervention of obesity-related medical complications.
作者 Mustafa Abdo Saif Dehwah Aimin Xu Qingyang Huang
机构地区 Hubei Key Lab of Genetic Regulation and Integrative Biology Department of Medicine
出处 《Journal of Genetics and Genomics》 SCIE CAS CSCD 2012年第1期11-18,共8页 遗传学报（英文版）
基金 supported by the National Basic Research Program of China(973 Program)(No.2011CB504004) and self-determined research funds of CCNU from the colleges' basic research and operation of MOE
关键词 MICRORNAS Type 2 diabetes OBESITY MicroRNAs Type 2 diabetes Obesity
分类号 R587.1 [医药卫生—内分泌] R589.2 [医药卫生—内分泌]
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参考文献16

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二级参考文献26

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共引文献16

同被引文献67

引证文献21

二级引证文献53

Journal of Genetics and Genomics
2012年 第1期

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