腔隙性脑梗死老年患者并发肺部感染多因素分析

Multivariate analysis of elderly patients with lacunar infarction complicated by lung infection

目的:探讨腔隙性脑梗死老年患者并发肺部感染因素及其危险因素。方法:收集该院2001年1月至2011年1月收治的腔隙性脑梗死并发肺部感染老年患者58例,及单纯随机选取同期未并发肺部感染腔隙性脑梗死老年患者47例,并对其临床资料进行回顾性分析。结果:两组29种影响因素的单因素分析表明,其中有10种因素的差异具有统计学意义(P<0.05)。这些因素分别为年龄、2型糖尿病、意识障碍、延髓性麻痹、血氧饱和度、二氧化碳分压、血清白蛋白、免疫球蛋白IgG、β2微球蛋白及D二聚体。将单因素分析中差异具有统计学意义的10种因素进行Logistic多因素回归分析显示,年龄、2型糖尿病、血清白蛋白、β2微球蛋白及D二聚体是腔隙性脑梗死患者并发肺部感染的独立危险因素。结论:控制好血糖、提高血清白蛋白水平、减少β2微球蛋白含量、降低D二聚体含量对预防腔隙性脑梗死患者并发肺部感染有较重要的临床意义。

Objective： To study the risk factors of pulmonary infection factors in elderly patients with lacunar infarction. Methods： From January 2001 to January 2011, lacunar infarction were treated in elderly patients with pulmonary infection in 58 cases, in 47 elderly patients with lacunar infarction without pulmonary infection in the same period were randomly selected as controls. The clinical data were retrospectively analyzed. Results： There were 29 factors in the univariate analysis showed that, among them, 10 factors were significantly different, including age, type 2 diabetes, disturbance of consciousness, bulbar paralysis, endotracheal intubation, tracheal incision, application of breathing machines, oxygen saturation, carbon dioxide partial pressure, serum albumin, immunoglobulin IgG, f12 mieroglobulin, D dimer in the univariate analysis statistically significant differences in factors of 15 Logistic regression analysis showed： age, type 2 diabetes, serum albumin, f12 microglobulin, D dimmer in patients with lacunar infarction pulmonary infection were independent risk factors. Conclusion： The good control of blood sugar, increased serum albumin levels, reduce the f12 microglobulin, lower D dimmer in the prevention of pulmonary patients with lacunar infarction infection have a higher clinical significance.