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神经炎症在阿尔茨海默病发病机制中的作用 被引量：12

Role of neuroinflammation in pathogenesis of Alzheimer's disease
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摘要 阿尔茨海默病(AD)是目前最为常见的一种神经退行性疾病,其病因及发病机制至今还不是很清楚。近几年,越来越多的研究发现,神经炎症在AD的发生发展过程中发挥着重要作用。其中,小胶质细胞的激活及其产生的炎症因子是AD神经炎症的主要表现。此外,在AD疾病过程中,外周侵入脑内的淋巴细胞及炎症因子也参与了AD的神经炎症。因此,研发副作用小的非甾体类抗炎药有望成为防治AD的新靶点。 Alzheimer＇s disease（AD） is the most common neurodegenerative disease, and its etiology and pathogenesis are still not very clear so far. In recent years, a growing number of studies have found that neuroinflammation plays an impor- tant role in the development of AD. The activation of microglia and the inflammatory eytokines produced by the cells repre- sent the neuroinflammation in many ways. In addition, peripheral lymphocytes and inflammatory cytokines invading into the brain in AD progress join the neuroinflammation as well. Therefore,the investigation of non-steroidal anti-inflammatory drugs with small side effect may become a new target for prevention and treatment of AD.
作者 张军 柯开富 邱一华 彭聿平
机构地区 南通大学医学院生理学系 南通大学附属医院神经内科
出处 《南通大学学报（医学版）》 2012年第1期44-47,共4页 Journal of Nantong University(Medical sciences)
基金 国家自然科学基金资助项目(30870819)
关键词 阿尔茨海默病 神经炎症 小胶质细胞 淋巴细胞 Alzheimer＇ s disease neuroinflammation microglia lymphocytes
分类号 R749.16 [医药卫生—神经病学与精神病学]
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参考文献39

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二级参考文献15

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二级引证文献66

南通大学学报（医学版）
2012年 第1期

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