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转录因子T-复合物蛋白10样基因研究进展

Advances in research on the T-complex protein 10 like gene
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摘要 转录因子T-复合物蛋白10样基因(TCP10L)是近年来新发现的转录抑制因子,仅在灵长类动物内表达。它能通过亮氨酸拉链与凋亡相关蛋白激酶等相互作用。由于TCP10L仅在人类的睾丸和肝脏中表达,因此TCP10L对于研究人类睾丸和肝脏疾病具有重要意义。 A novel human gene T-complex 10 like（TCP10L） with transcriptional inhibition activity has been cloned recently.It might interact with death associated protein kinase（DAPK） through the leucine zipper domaincontaining region.Researches revealed that TCP10L was expressed specifically in human testis and liver,therefore,it is of potential value to help us understand the molecular mechanisms of testis and liver diseases.
作者 张爱贤 李立人 曹晓蕾
机构地区 南通大学附属医院消化内科 南通大学医学院病理学教研室
出处 《南通大学学报（医学版）》 2012年第1期51-53,共3页 Journal of Nantong University(Medical sciences)
基金 江苏省高校自然科学基金项目(10KJB320012) 江苏省六大人才高峰资助项目(第七批) 江苏省2011年度普通高校研究生科研创新计划资助项目(CXZZ11_0642) 2011年度南通大学研究生科技创新计划项目(YKC11007)
关键词 原发性肝癌 T-复合物蛋白10样基因 凋亡相关蛋白激酶 primary liver cancer T-complex 10 like gene death associated protein kinase
分类号 R735.7 [医药卫生—肿瘤]
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参考文献25

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二级参考文献25

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南通大学学报（医学版）
2012年 第1期

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