CEA铁蛋白ADA及抗结核抗体联合检测在胸腔积液诊断中的意义

目的探讨癌胚抗原(CEA)、铁蛋白、腺苷脱氢酶(ADA)以及抗结核抗体在胸腔积液性质诊断中的意义。方法对2010年1月—2011年9月胸腔积液患者107例(恶性积液39例、结核性积液43例、炎性积液25例),进行胸腔穿刺抽液,将胸腔积液分别进行CEA、铁蛋白、ADA、抗结核抗体进行测定。并根据设定的特殊临界值划分阳性阴性。结果 CEA敏感性特异性有效性分别为(51.3%,98.5%,81.3%),铁蛋白敏感性特异性有效性分别为(56.4%,89.7%,77.6%),ADA敏感性特异性有效性分别为(48.8%,98.4%,78.5%),抗结核抗体敏感性特异性有效性分别为(51.2%,89.1%,73.8%)CEA与铁蛋白联合检测敏感性特异性有效性分别为(92.3%,88.2%,90.7%),ADA与抗结核抗体联合检测敏感性特异性有效性分别为(90.7%,87.5%,88.8%)。结论 CEA和铁蛋白在癌性胸水诊断中具有至关重要的意义;ADA、抗结核抗体是结核性胸膜炎特征性标志物。采用联合检测的方法可以有效提高检出率,减少漏诊发生。

Object Explore the carinoembryonic(CEA) Serum Ferritin(SF) Adenosine dehydrogenase(ADA) Anti-tuberculosis antibody in the diagnosis of pleural effusion significance Means From January 2010 to 2011 September 107 cases pleural effusion(39 cases of malignant effusion,43 cases of tuberculous effusion inflammatory effusion in 25 cases) were with were taken by puncture of pleural effusion The pleural effusion were respectively measured in the CEA Serum ferritin ADA Anti-TB antibody According to the special critical value set into positive and negative Results The CEA sensitivity specificity validity respectively is(51.3%,98.5%,81.3%) The Serum Ferritin sensitivity specificity validity respectively(56.4%,89.7%,77.6) The ADA sensitivity specificity validity respectively(51.2%,89.1%,73.8%) Anti-tuberculosis antibody sensitivity specificity validity respectively(51.2%,89.1%73.8%) CEA and Serum Ferritin united detection sensitivity specificity effectiveness which are(92.3%,88.2%,90.7%) ADA and Anti-tuberculosis antibody united detection sensitivity specificity effectiveness which are(90.7%,87.5%,88.8%).Conclusion In the cancer diagnosis of hydrothorax the CEA and Serum Ferritin are vital significance.ADA and Anti-tuberculosis antibody are the markers of tuberculosis pleurisy。The joint-test method can effectively improve the detection rate,reduce the misdiagnosis rate.