4-甲基-7-羟基-8-醛香豆素的合成与表征

Synthesis and Characterization of Formyl Coumarin Compounds

采用间苯二酚和乙酰乙酸乙酯为原料,合成了4-甲基-7-羟基香豆素。4-甲基-7-羟基香豆素和六次甲基四胺在冰醋酸中反应,简单处理后得到4-甲基-7-羟基-8-醛基香豆素。对所合成的醛基香豆素采用IR、1HNMR进行了结构表征和确认。该反应操作简单,后处理简便,产率较高。

4-Methyl-7-hydroxyl coumarin was prepared by the reaction of the resorcinol with the ethyl acetoacetate and then 4-methyl-7-hydroxyl-8-formyl coumarin was obtained by the reaction of the urotropine with the 4-methyl-7-hydroxyl coumarin in the glacial acetic acid after the simple treatment.The compound＇s structure was conformed by the IR,1HNMR spectrum.This procedure has the advantage of easiness to handle,simple treatment and moderate yield.