别嘌醇对慢性肾功能衰竭合并高尿酸血症的干预效果分析被引量：1

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摘要目的探讨应用别嘌醇降低血尿酸水平对控制不同程度的慢性肾功能衰竭进展的作用.方法患者分两大组分别比较.轻中度慢性肾功能衰竭患者伴有高尿酸血症者51例,随机分为别嘌醇治疗组24例和对照组27 例;重度慢性肾功能衰竭患者（未行透析治疗或血清肌酐〈707 μmmol/L）伴高尿酸血症患者48例,随机分为别嘌醇治疗组23例和对照组25例.别嘌醇治疗组患者给予别嘌醇200 mg/d,控制血尿酸于正常范围内;慢性肾功能衰竭药物治疗方案2组相同.观察期限12个月,比较两大组中别嘌醇治疗组与对照组患者慢性肾功能衰竭进展的差异.结果轻中度慢性肾功能衰竭患者中,别嘌醇治疗组与对照组血肌酐和尿素氮水平均有升高,别嘌醇治疗组肌酐和尿素氮水平上升幅度低于对照组（P〈0.05）,同时别嘌醇治疗组血尿酸明显低于对照组（P〈0.05）.重度慢性肾功能衰竭患者中,别嘌醇治疗组与对照组血肌酐和尿素氮水平均有升高且上升幅度无明显差异（P〉0.05）,但别嘌醇治疗组血尿酸明显低于对照组（P〈0.05）.结论别嘌醇通过降低血尿酸水平,可明显延缓轻中度慢性肾功能衰竭的进展,但不能控制重度慢性肾功能衰竭的进展.

作者赵旭东崔爱东

机构地区徐州医学院附属医院肾内科

出处《徐州医学院学报》 CAS 2012年第1期48-50,共3页 Acta Academiae Medicinae Xuzhou

关键词肾功能衰竭慢性别嘌醇尿酸

分类号 R692.5 [医药卫生—泌尿科学]

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