甘宁颗粒对慢性乙型病毒性肝炎患者血清IFN-γ影响的研究

Study on the Effect of Ganning Particles on IFN-γ of Chronic Hepatitis B Patients

目的:观察甘宁颗粒治疗慢性乙型病毒性肝炎的临床疗效及其对慢性乙型病毒性肝炎患者血清IFN-γ水平的影响。方法:将60例慢性乙型病毒性肝炎患者随机分为治疗组与对照组各30例,2组均采用保肝降酶治疗,治疗组同时予甘宁颗粒,对照组只给予保肝降酶治疗,对2组患者治疗前后的临床症状、血清肝脏生化功能ALT、AST,血清病毒学标志HBV DNA和血清IFN-γ水平进行比较、分析及评价。结果:甘宁颗粒改善慢性乙型病毒性肝炎患者的临床症状,治疗6个月后临床症状的总有效率为76.7﹪,与对照组比较有统计学意义(P<0.05)。甘宁颗粒治疗后血清IFN-γ水平明显升高(P<0.01),血清肝脏生化功能ALT、AST指标明显好转(P<0.01),血清病毒学标志HBV DNA的滴度下降(P<0.05)。与对照组比较有统计学意义(P<0.05)。临床试验中2组均未见不良反应。结论:甘宁颗粒治疗慢性乙型病毒性肝炎疗效肯定,能显著改善慢性乙型病毒性肝炎患者的临床症状,提高患者血清IFN-γ水平。

Objective: To observe the clinical effect of Ganning particles on the treatment of chronic hepatitis B patients and their IFN-γ level changes.Methods: 60 patients were randomly divided into one treatment group and one control group,30 patients per group.Both groups were treated with liver-protecting and enzyme-lowing medicine,but the treatment group was added with Ganning particles.The symptoms,the serum liver biochemical functions ALT,AST,the serum HBV DNA and the serum virology signs IFN-γ levels of the two groups were compared,analyzed and evaluated before and after the treatment.Results: The symptoms of the patients in Ganning particles group improved 6 months later,and the total effective rate was 76.7%.Compared with the control group the difference was statistically significant(P<0.05).The serum IFN-γ of the patients in the treatment group significantly increased(P<0.01) after the treatment,their ALT,AST parameters of the serum biochemical liver significantly improved(P<0.01),and their serum HBV DNA titer declined(P<0.05).Compared with the control group,the difference was statistically significant(P<0.05).There were no adverse reactions in the two groups.Conclusion: Ganning particles has a good effect on the treatment of the chronic hepatitis B patients,and can significantly improve their symptoms and raise their serum IFN-γ level.