期刊文献+

β-防御素与牙周健康

The importance of β-defensins in periodontal health
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摘要 口腔上皮不仅作为外界环境与宿主之间的一道物理屏障,还具有分泌多种抗菌肽参与天然免疫的作用。其中β-防御素家族具有广谱抗菌的作用,对口腔内的多种细菌有抑制作用,从而保护宿主的健康。本文就β-防御素在牙龈组织的表达及其与牙周可疑致病菌的相互作用关系作一综述。 The β-defensins have a broad spectrum of activity against both Gram-negative and Gram-positive bacteria,and play an important role in the innate immune responses.In this review we summarize the characteristics of β-defensins during the process of periodontal disease.
作者 石雪 丁一
出处 《牙体牙髓牙周病学杂志》 CAS 北大核心 2012年第2期114-117,共4页 Chinese Journal of Conservative Dentistry
关键词 Β-防御素 牙周病 口腔细菌 天然免疫 β-defensins periodontal disease oral bacteria inn ate immunity
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参考文献24

  • 1Dale BA.Periodontal epithelium:a newly recognized role inhealth and disease[J].Periodontol,2000,2002,30:70-78.
  • 2Gznz T.Defensins:antimicrobial peptides of vertebrates[J].CR Biol,2004,327(6):539-549.
  • 3Premratanachai P,Joly S,Johnson GK,et al.Expression andregulation of novel human beta defensins in gingival keratinocytes[J].Oral Microbiol Immunol,2004,19(2):111-117.
  • 4Lu Q,Samaranayake LP,Darveau RP,et al.Expression of hu-man beta-defensin-3 in gingival epithelia[J].J PeriodontalRes,2005,40(6):474-481.
  • 5Dale BA,Kimball JR,Krisanaprakornkit S,et al.Localized an-timicrobial peptide expression in human gingival[J].J Perio-dontal Res,2001,36(5):285-294.
  • 6Dale BA,Krisanaprakornkit S.Defensin antimicrobial peptides inthe oral cavity[J].J Oral Pathol Med,2001,30(6):321-327.
  • 7Dale BA,Fredericks LP.Antimicrobial peptides in the oral en-vironment:expression and function in health and disease[J].Curr Issues Mol Biol,2005,7(2):119-133.
  • 8Dunsche A,Acil Y,Dommisch H,et al.The novel human beta-defensin-3 is widely expressed in oral tissues[J].Eur J OralSci,2002,110(2):121-124.
  • 9张旭,束蓉.β-防御素基因在牙龈组织中的表达[J].口腔医学研究,2006,22(1):34-37. 被引量:4
  • 10Varear-Sengul S,Demirci T,Sen BH,et al.Human beta defen-sin-1 and-2 expression in gingiva of patients with specific perio-dontal diseases[J].J Periodontal Res,2007,42(5):429-437.

二级参考文献12

  • 1Bensch KW,Raida M,Magert HG,et al.HBD-1:A novel beta-defensin from human plasma[J].FEBS Lett,1995,368(2):331 -335.
  • 2Dunsche A,Acil Y,Siebert R,et al.Expression profile of human defensins and antimicrobial proteins in oral tissues[ J ].J Oral Pathol Med,2001,30(3):154-158.
  • 3Dunsche A,Acil Y,Dommisch H,et al.The novel human beta-defensin-3 is widely expressed in oral tissues[ J ].Eur J Oral Sci,2002,110(2):121-124.
  • 4Michael Mthews,Hong Peng Jia,Jane M,et al.Production of β-Defensin Antimicrobiaol Peptides by the oral Mucosa and Salivary Glands[ J ].Infect Immun,1999,67 (6):2 740-2 745.
  • 5Harder J,Meyer Hoffert U,Teran LM,et al.Mucoid Pseudomonas aeruginosa,TNF-alpha,and IL-1 beta,but not IL-6,induce human beta defensin -2 in respiratory epithelia[ J ].Am J Respir Cell Mol Biol,2000,22 (6):714-721.
  • 6Harder J,Bartels J,Christophers E,et al.Isolation and characterization of human beta-defensin-3,a novel human inducible peptide antibiotic[J].J Biol Chem,2001,276 (8):5 707 -5 713.
  • 7Bissell J,Joly S,Johnson GK,et al.Expression of beta-defensins in gingival health and inperiodontal disease[ J ].J Oral Pathol Med,2004,33 (5):278-285.
  • 8Lu Q,Jin L,Darveau RP,Samaranayake LP[ J ].J Periodontal Res,2004,39(4):221 -227.
  • 9Krisanaprakornkit S,Kimball JR,Weinberg A,et al.Inducible expression of human beta-defensin 2 by Fusobacterium nucleatum in oral epithelial cells:multiple signaling pathways and role of commensal bacteria in innate immunity and the epithelial barrier[J].Infect Immun,2000,68(5):2 907 -2 915.
  • 10Feucht EC,DeSanti CL,Weinberg A.Selective induction of human beta-defensin mRNAs by Actinobacillus actinomycetemcomitans in primary and immortalized oral epithelial cells[ J ].Oral Microbiol Immunol,2003,18 (6):359-363.

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