胎盘生长因子作为预测子痫前期标记物可行性求证分析

目的:胎盘生长因子作为预测子痫前期标记物可行性求证分析。方法:随机选择产妇分组,研究组:足月分娩子痫前期孕妇48例;对照组:正常足月分娩孕妇48例。分别检测两组孕妇在不同孕周血清中PLGF含量,以及产前血清中PLGF含量和产后胎盘灰度值。两组孕妇年龄、体重、孕周无统计学差异,均无其他妊娠合并症及并发症。产前住院,于次日清晨,检测静脉血清中PLFG。产后立即采集胎盘标本,测定视野内胎盘合体滋养细胞阳性染色的灰度。结果:研究组血清及胎盘组织中PLGF的表达均明显低于对照组,两组灰度值数据显著差异,研究组明显低于对照组(P<0.05)。对照组足月胎盘组织中,绒毛发育良好,绒毛干血管扩张明显,间质细胞少,可见较多的合体细胞结节及合体细胞桥。研究组胎盘绒毛发育欠佳,绒毛血管扩张不良,间质细胞增生,滋养细胞层的合体细胞结节及合体细胞桥较少。结论:PLGF在PE组孕妇的外周血和胎盘组织中表达降低,子痫前期患者胎盘合体滋养细胞存在超微结构破坏,胎盘生长因子作为预测子痫前期标记物可行。

Objective： placental growth factor as a predictor of preeclampsia feasibility verification analysis. Methods： random selection, study group： full-term delivery of 48 pregnant women with preeelampsia; the control group： 48 cases of normal full-term delivery of pregnant women. Two groups of pregnant women were detected in different gestational serum PLGF content, and the content of PLGF in serum and antenatal postpartum placenta gray value. Two groups of pregnant women age, weight, gestational weeks no statistical difference, no other pregnancy complications. Antepartum hospitalization, in the morning, the detection of venous serum PLFG. The immediate postpartum placental specimens in the field of acquisition, determination of placental syncytiotrophoblast positive staining in the gray. Results： Study Group on serum and placenta tissue PLGF expression were significantly lower than the control group, two groups of gray value data significantly, the study group was significantly lower than that of control group （P〈0.05）.Group term placenta chorionic villi, well-developed, villous stem vascular dilatation, interstitial cells less visible, many tegumental ceils nodules and tegumental cells bridge. Research group of placental villi growth owes beautiful, villous vasodilator adverse, Leydig cell hyperplasia, trophoblastic layer syncytial cell nodules and tegumental cells bridge less. Conclusion： PLGF in PE group in the peripheral blood of pregnant women and expressed in placental tissues is reduced, patients with preeclampsia placental syncytiotrophoblast in uhrastructural damage, placental growth factor as a predictor of preeclampsia markers feasible.