摘要
目的比较41例老年非小细胞肺癌适形放疗与NP方案同步化疗与单纯放疗的疗效差异及不良反应。方法分析2008年7月至2010年7月老年性(>65岁)非小细胞肺癌患者41例,其中21例接受同步放化疗,放疗为适形放疗,化疗采用长春瑞滨胶囊加顺铂;20例仅采用适形放疗。结果患者中位随访时间均为1年,治疗后3个月、1年复查,同步放化疗组局部控制率76.2%,单纯放疗组局控率65.0%;同步放化疗组1年生存率为81.0%,放疗组1年生存率为70.0%。差异无统计学意义(P>0.05);两组患者放射性肺炎的发生率分别为19.0%与15.0%,差异无统计学意义(P>0.05);两组患者白细胞下降发生率分别为42.9%与10.0%,差异有统计学意义(P<0.05)。结论 NP方案同步放化疗的综合治疗改善老年非小细胞肺癌生活质量,但局部控制率及1年生存率较单纯放疗未见提高。另外,NP方案同步放化疗治疗组毒副作用与单纯化疗组相比,发生率虽然高,但可以耐受。
Objective To evaluate the different efficacy and side effects between concurrent three-dimensional conformal radiotherapy（3 d-CRT） plus chemotherapy and 3 d-CRT in 41 aged patients with non-small cell lung cancer（NSCLC）.Methods From July.2008 to July.2010,41 of aged patients with NSCLC in our department were retrospectively analyzed.Among them 21 cases received 3 d-CRT plus chemotherapy with NP regimen and 20 cases received 3 d-CRT only.Results The median follow-up was 12 months.After the end of treatment,the patients received 3-month,1-year review of the relevant inspection.The local control rate was not statistically different between the two groups（76.2% vs 65.0%）.The Kaplan-Meier survival rate,one-year survival rates in concurrent 3 dCRT plus chemotherapy group were 81.0% and 70.0% in radiotherapy group.Radiation pneumonitis occurring in two groups was not statistically different（P0.05）.The decline of leucocyte in two groups was statistically different（P0.05）.Conclusion To the aged NSCIC patients,concurrent chemotherapy plus 3 d-CRT can improve quality of life and it is good in toleration for the patients.However,the local control and survival rate in this study does not increase.
出处
《中国实用医药》
2012年第1期10-12,共3页
China Practical Medicine
