顺尔宁联合雾化吸入治疗儿童哮喘急性发作100例临床分析

Effect of leukotriene receptor antagonist combined with atomized inhalation in treatment of 100 acute paroxysmal asthma

目的观察顺尔宁联合雾化(普米克令舒和万托林)治疗儿童哮喘急性发作的临床疗效。方法选取2009年1月至2010年12月符合儿童哮喘诊断标准的哮喘急性发作患儿100例(轻、中度),随机分为两组:对照组50例,予普米克令舒1.0mg/次和万托林2.5mg/次混合后加生理盐水至3～4ml,2次/d,经氧气驱动雾化吸入;治疗组50例,在对照组用药的基础上加口服顺尔宁,疗程为10d。比较两组临床症状、体征消失时间及肺功能测定(FEV1、PEF)。结果治疗组的临床症状消失时间比对照组明显缩短(P<0.05),两组治疗前、治疗后10d比较肺功能各项指标差异有统计学意义(P<0.01)。结论顺尔宁联合雾化吸入治疗儿童哮喘急性发作,能迅速缓解临床症状,改善肺功能,具有协同作用,且用药安全性高,值得临床推广应用。

Objective To study the efficacy of leukotriene receptor antagonist combination with atomized inhalation of ventolin and pulmicort in treatment of acute Paroxysmal asthma.Methods 100 children with acute Paroxysmal Asthma in our hospital were randomly divided into 50 cases of experimental group and 50 cases of normal group;in expeimental group took atomized inhalation of ventolin and pulmicort twice every day combination with leukotriene receptor antagonist,in normal group took atomized inhalation of ventolin and pulmicort twice every day.Course of treatment of all patients was 10 days.The times of the two groups＇s symptoms disappear and the pulmonary function（FEV1and PEF） were detected.Results The times of symptoms disappear of the expeimental group was shorter than that of normal group（P 0.05）.FEV1 and PEF after therapy in the experimental group were significantly higher than those of normal group（P 0.01） after therapy.Conclusion Leukotriene receptor antagonist combination with atomized inhalation of ventolin and pulmicort can improve pulmonary function in treatment of acute paroxysmal asthma and is more effective than atomized inhalation of ventolin and pulmicort alone.