摘要
本文报道蛇毒溶栓素(ATE)对家犬、猕猴体内外凝血作用的影响.体外实验表明:ATE具有类凝血酶样作用,能使去钙血浆和纤维蛋白原直接凝固,它不激活Ⅻ因子,产生是非交联的纤维蛋白,并且有纤溶酶样作用,能直接溶解纤维蛋白,产生抗凝作用.体内实验表明:ATE显著延长全血凝固时间、凝血酶时间和凝血酶原时间,注射ATE后血浆中纤维蛋白原降低,优球蛋白溶解时间缩短,三P试验阳性,血小板减少.体内外实验表明,ATE具有去纤、纤溶、抗血小板功能和抗凝效应.
In this paper we report detailed studies of the effects of antith-rombosis enzymes (ATE) on blood coagulation, both in vitro and vivo experi- ments in animals (dogs, monkeys) treated with ATE, Our results show that ATE posseses thrombin-like and fibrinolytic enzyme activity.It converts fibr-inogen directly into unstable fibrin clots and can directly dissolve the fibrin.These effects cause : a marked prolongation in the whole blood coagulation ti-me, prothrombin time, thrombin time, plasma recalcification time and kaolin partialthromboplastin time; a marked decrease in the plasma fibrinogen con-centration and platelet count; shortening of the eulobulin lysis time; and also a Positive plasma protamine paracoagulation test.Thus, it may be concluded that ATE produces the effects of defibrination, fibrinolysis, anticoagulation and inhibition of the platelet fuctions.
关键词
蛇毒
溶栓素
凝血功能
凝血酶
Snake Venom
Antithrombosis Enzymes
Coagulation Functions
Thrombin-like Enzyme
Fibrinolytic Enzyme
