摘要
AIM:To explore the potential risk factors related to gastrointestinal cancer in northern China.METHODS:A total of 3314 cases of gastrointestinal cancer(esophageal,gastric,pancreatic and biliary) and 2223 controls(including healthy individuals,glioma and thyroid cancer) were analyzed by case-control study.Multivariable logistic regression analysis was applied to evaluate the association between different cancers and hepatitis B surface antigen,sex,age,blood type,diabetes,or family history of cancer.RESULTS:Type 2 diabetes was significantly associated with gastric,biliary and pancreatic cancer with an OR of 2.0-3.0.Blood type B was significantly associated with esophageal cancer [odd ratio(OR) = 1.53,95% confidence interval(CI) = 1.10-2.14] and biliary cancer(OR = 1.49,95% CI = 1.09-2.05).The prevalence of type 2 diabetes was significantly higher in gastric,biliary and pancreatic cancers compared with other groups,with ORs ranging between 2.0 and 3.0.Family history of cancer was strongly associated with gastrointestinal compared with other cancers.CONCLUSION:Blood type B individuals are susceptible to esophageal and biliary cancer.Type 2 diabetes is significantly associated with gastric,biliary and especially pancreatic cancer.
AIM： To explore the potential risk factors related to gas- trointestinal cancer in northern China, METHODS： A total of 3314 cases of gastrointestinal cancer （esophageal, gastric, pancreatic and biliary） and 2223 controls （including healthy individuals, glioma and thyroid cancer） were analyzed by case-control study. Multivariable logistic regression analysis was applied to evaluate the association between different cancers and hepatitis B surface antigen, sex, age, blood type, diabe- tes, or family history of cancer.RESULTS： Type 2 diabetes was significantly associated with gastric, biliary and pancreatic cancer with an OR of 2.0-3.0. Blood type B was significantly associated with esophageal cancer [odd ratio （OR） = 1.53, 95% confi- dence interval （CI） = 1.10-2.14] and biliary cancer （OR = 1.49, 95% CI = 1.09-2.05）. The prevalence of type 2 diabetes was significantly higher in gastric, biliary and pancreatic cancers compared with other groups, with ORs ranging between 2.0 and 3.0. Family history of cancer was strongly associated with gastrointestinal compared with other cancers. CONCLUSION： Blood type B individuals are suscepti- ble to esophageal and biliary cancer. Type 2 diabetes is significantly associated with gastric, biliary and espe- cially pancreatic cancer.
基金
Supported by The National Basic Research Program,973 Pro-gram No. 2010CB912802 and No. 2006CB910700
the China National Science Foundation,No. 81071953,No. 30890033 and No. 30620120433
the Chinese Academy of Sciences No.KSCX1-YW-R-40
the 44 Postdoctoral Fund of China,No.20080441314
