甘精胰岛素治疗新诊断2型糖尿病患者的效果评价

Treatment evaluation of insulin glargine in newly diagnosed type 2 diabetes mellitus

目的评价甘精胰岛素治疗新诊断T2DM患者的降糖效果及对胰腺功能的影响。方法新诊断T2DM患者50例,随机分为治疗组(甘精胰岛素联合二甲双胍、阿卡波糖)和对照组(格列美脲联合二甲双胍、阿卡波糖),治疗12周。结果治疗后两组HbA1c、FBG、2hBG较治疗前显著下降(P<0.01);治疗组FC-P及2hC-P显著高于对照组(P<0.05),低血糖发生次数显著低于对照组(P<0.05)。结论甘精胰岛素联合口服药物能够有效降低血糖、促进胰岛β细胞功能恢复、低血糖发生少,为新诊断T2DM患者行之有效的降糖方案。

Objective To evaluate the treatment of insulin glargine in newly diagnosed type 2 diabetes mellitus and the effect on pancreatic islet β cells. Methods Fifty patients with newly diagnosed type 2 diabetes were randomly divided into treatment group（n=25,insulin glargine combined with metformin and acarbose） and control group（n=25,glimepiride combined with metformin and acarbose）,and all the patients were treated for 12 weeks. Results There were no significant differences between two groups in HbA1c,FBG,2hBG,FC-P and 2hC-P before the test.HbA1c,FBG,2hBG of the two groups decreased after the treatment（P〈0.01）;FC-P and 2hC-P in the treatment subjects were higher than those in the control subjects（P〈0.05）;Compared with the control group,the frequency of hypoglycemia in the treatment group was lower during the test（P〈0.05）. Conclusion Combined treatment of insulin glargine with metformin and acarbose for newly diagnosed type 2 diabetes mellitus,can effectively reduce fasting and postprandial blood glucose with fewer hypoglycemia,and also recover the function of islet β cells.So,it will provide an effective therapy for newly diagnosed type 2 diabetes mellitus.