绿茶抑制黄曲霉毒素B_1致大鼠肝癌作用的时间一效应关系

TIME-RELATED INHIBITORY EFFECT OF GREEN TEA DIET ON AFLATOXIN B_1-INDUCED HEPATOCARCINOGENESIS IN RAT

本研究应用我室建立的AFB_1致大鼠肝癌作用短期体内实验模型,探讨绿茶在动物摄入AFB_1前、中、后等不同时期,对AFB_1致肝癌作用的影响.结果表明,绿茶与某些已知的抑癌物不同:它对AFB_1致肝癌作用的抑制效果不受使用时间的影响,不论用于给AFB_1前、中、后期,均有明显的抑制作用.本结果为绿茶作为一种安全有效的抑制AFB_1致肝癌作用的化学预防剂,再次提供有力的依据.

Green tea diet was given to the rats either before, during or after AFB_1 exposure in order to test the time-effect of green tea on AFB_1-induced hepatocarcinogenesis for short-term model in vivo experiments.The results showed; that no matter at what time it was given, green tea always exerted significant inhibitory effect on the development of AFB_1-induced hepatocarcinogenesis.This was rather different from the time-related effect of some other chemicals such as phenobarbital, BHT and BHA.This result suggests that green tea can be used as a safe and effective chemoprevention agent for inhibiting AFB_1-induced hepatocarcinogenesis.