三种仪器测量准分子激光原位角膜磨镶术前后中央角膜厚度的对比研究

Comparison of Three Different Instruments Measuring Central Corneal Thickness before and after Laser in situ Keratomileusis

目的对比A型超声角膜测厚仪、OrbscanⅡ眼前节分析仪和Pentacam眼前节分析仪测量准分子激光原位角膜磨镶术(LASIK)前后中央角膜厚度的差异。方法 2010年10月-2011年3月,分别使用A型超声角膜测厚仪、OrbscanⅡ和Pentacam眼前节分析仪测量137例(274只眼)近视患者LASIK前后中央角膜厚度,并对测量结果进行配对t检验和Pearson相关性分析。结果 LASIK术前A型超声、OrbscanⅡ和Pentacam测量值分别为(526.6±34.1)、(516.6±34.2)、(539.8±31.5)μm,Pentacam测量值较A型超声和OrbscanⅡ测量值高,差异有统计学意义(P<0.05),而A型超声和OrbscanⅡ测量值之间差异无统计学意义(P>0.05);LASIK术后6个月A型超声、OrbscanⅡ和Pentacam测量值分别为(448.2±48.5)、(391.9±58.5)、(451.5±46.4)μm,LASIK术后A型超声和Pentacam测量值无差异(P>0.05),而OrbscanⅡ测量值较A型超声和Pentacam低;Pearson相关分析显示,LASIK术后Pentacam和A型超声CCT测量值呈高度相关(P<0.05)。结论 3种仪器的中央角膜厚度测量值不可互换,LASIK术后A型超声和Pentacam量值较为准确。

Objective To compare the difference in measurements of central corneal thickness（CCT） using A-scan,OrbscanⅡand Pentacam before and after laser in situ keratomileusis（LASIK）.Methods Between October 2010 and March 2011,the CCT of 137 patients（274 eyes） were measured by A-scan,OrbscanⅡ and Pentacam,and the results were analyzed by paired t-tests and Pearson correlation.Results Before LASIK,the values of CCT measured by A-scan,OrbscanⅡ and Pentacam were（526.6 ± 34.1）,（516.6 ± 34.2）,and（539.8 ± 31.5） μm respectively;paired t-tests showed the CCT values obtained with Pentacam were significantly higher than those with other methods（P0.05）,but there were no statistical significant differences between OrbscanⅡand Pentacam measurements（P0.05）.Six months after LASIK,the values of CCT measured by A-scan,OrbscanⅡand Pentacam was（448.2 ± 48.5）,（391.9 ± 58.5）,and（451.5 ± 46.4） μm respectively;the CCT values obtained with A-scan and Pentacam didn＇t differ much from each other（P0.05）,and the CCT values obtained with OrbscanⅡwere lower than those obtained with A-scan and Pentacam.There was a high correlation between A-scan and Pentacam measurements.Conclusion The these methods measuring CCT could not be used interchangeably,and A-scan and Pentacam after LASIK were more precise than OrbscanⅡ.