87例新生儿败血症病原菌及耐药性分析

Pathogens and antibiotic resistance in 87 cases of neonatal sepsis

目的分析近年我院新生儿败血症病原菌种类及细菌耐药情况,为临床合理用药提供参考。方法对2008年6月至2011年6月87例新生儿败血症患儿的血培养和药敏实验结果行回顾性分析。结果前3位检出的菌种分别为凝固酶阴性葡萄球菌(45株,51.7%)、金黄色葡萄球菌(21株,24.1%)、大肠埃希菌(12株,13.8%);革兰阳性球菌对青霉素、红霉素的耐药率较高,对万古霉素、替考拉宁全敏感;革兰阴性菌对依诺沙星、复方磺胺甲噁唑的耐药率较高,对亚胺培南全敏感。结论凝固酶阴性葡萄球菌是新生儿败血症最常见的病原菌,对常用抗菌药物有不同程度的耐药;根据血培养结果选用敏感抗菌药物,可减少细菌耐药性的产生,提高疗效。

Objective To analyze the pathogen types and drug resistance status of the newborns with sepsis admitted to our hospital in recent years, and to provide reference for rational drug use in clinical practice. Methods The blood culture and drug sensitivity test of 87 newborns with sepsis from June 2008 to June 2011 were retrospectively analyzed. Results The top 3 most common pathogen types were coagulase negative Staphylococcus （45 strains, 51.7%）, Staphylococcus aureus （21 strains, 24.1%）, and Escherichia Coli （12 strains, 13.8% ）, respectively. Gram-positive cocci had a high resistance rate to penicillin and erythromycin, but had no resistance to vancomycin and teicopla- niru Gram-negative bacteria had a high resistance rate to enoxacine and trimethoprim-sulfamethoxazole, but were all sensitive to imipenem. Condusion Coagulase negative staphylococcus is the most common pathogenic bacterium causing neonatal sepsis and it is resistant to commonly used antibiotics at varioucs degrees. Choosing sensitive antibiotics according to the drug sensitivity tests may decrease the incidence of drug resistance and improve clinical efficacy.